RIPK2 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RIPK2

Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)

Predicted Functional Partners:

NOD1

0.998

NOD2

0.998

TRAF6

0.982

TRAF1

0.966

XIAP

0.965

CARD6

0.964

NGFR

0.960

BIRC3

0.952

G1SDV6_RABIT

0.942

TRAF5

0.942

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC3	G1SDV6_RABIT	ENSOCUP00000008710	ENSOCUP00000000605	Baculoviral IAP repeat containing 3.	Uncharacterized protein.	0.853
BIRC3	NOD1	ENSOCUP00000008710	ENSOCUP00000004572	Baculoviral IAP repeat containing 3.	Nucleotide binding oligomerization domain containing 1.	0.571
BIRC3	NOD2	ENSOCUP00000008710	ENSOCUP00000011052	Baculoviral IAP repeat containing 3.	Nucleotide oligomerization domain 2 protein.	0.537
BIRC3	RIPK2	ENSOCUP00000008710	ENSOCUP00000001326	Baculoviral IAP repeat containing 3.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.952
BIRC3	TRAF1	ENSOCUP00000008710	ENSOCUP00000004916	Baculoviral IAP repeat containing 3.	TNF receptor-associated factor.	0.969
BIRC3	TRAF5	ENSOCUP00000008710	ENSOCUP00000007884	Baculoviral IAP repeat containing 3.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.891
BIRC3	TRAF6	ENSOCUP00000008710	ENSOCUP00000026781	Baculoviral IAP repeat containing 3.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.857
BIRC3	XIAP	ENSOCUP00000008710	ENSOCUP00000028327	Baculoviral IAP repeat containing 3.	RING-type domain-containing protein.	0.853
CARD6	NOD1	ENSOCUP00000028753	ENSOCUP00000004572	Caspase recruitment domain family member 6.	Nucleotide binding oligomerization domain containing 1.	0.540
CARD6	RIPK2	ENSOCUP00000028753	ENSOCUP00000001326	Caspase recruitment domain family member 6.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.964
G1SDV6_RABIT	BIRC3	ENSOCUP00000000605	ENSOCUP00000008710	Uncharacterized protein.	Baculoviral IAP repeat containing 3.	0.853
G1SDV6_RABIT	NOD1	ENSOCUP00000000605	ENSOCUP00000004572	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.544
G1SDV6_RABIT	NOD2	ENSOCUP00000000605	ENSOCUP00000011052	Uncharacterized protein.	Nucleotide oligomerization domain 2 protein.	0.714
G1SDV6_RABIT	RIPK2	ENSOCUP00000000605	ENSOCUP00000001326	Uncharacterized protein.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.942
G1SDV6_RABIT	TRAF1	ENSOCUP00000000605	ENSOCUP00000004916	Uncharacterized protein.	TNF receptor-associated factor.	0.824
G1SDV6_RABIT	TRAF5	ENSOCUP00000000605	ENSOCUP00000007884	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.830
G1SDV6_RABIT	TRAF6	ENSOCUP00000000605	ENSOCUP00000026781	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.835
NGFR	RIPK2	ENSOCUP00000006606	ENSOCUP00000001326	Nerve growth factor receptor.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.960
NGFR	TRAF1	ENSOCUP00000006606	ENSOCUP00000004916	Nerve growth factor receptor.	TNF receptor-associated factor.	0.559
NGFR	TRAF5	ENSOCUP00000006606	ENSOCUP00000007884	Nerve growth factor receptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.461

page 1 of 4

Server load: low (34%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About