BARD1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

BARD1

BRCA1 associated RING domain 1. (751 aa)

Predicted Functional Partners:

BRCA1

0.999

BRCA2

0.994

BRIP1

0.993

MRE11

0.992

TOPBP1

0.991

NBN

0.987

RAD50

0.986

RAD51

0.983

BAP1

0.980

RBBP8

0.976

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAP1	BARD1	ENSOCUP00000041822	ENSOCUP00000001334	BRCA1 associated protein 1.	BRCA1 associated RING domain 1.	0.980
BAP1	BRCA1	ENSOCUP00000041822	ENSOCUP00000003366	BRCA1 associated protein 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.896
BAP1	MRE11	ENSOCUP00000041822	ENSOCUP00000012812	BRCA1 associated protein 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.505
BAP1	NBN	ENSOCUP00000041822	ENSOCUP00000029655	BRCA1 associated protein 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.506
BAP1	RAD50	ENSOCUP00000041822	ENSOCUP00000016215	BRCA1 associated protein 1.	Zinc-hook domain-containing protein.	0.521
BARD1	BAP1	ENSOCUP00000001334	ENSOCUP00000041822	BRCA1 associated RING domain 1.	BRCA1 associated protein 1.	0.980
BARD1	BRCA1	ENSOCUP00000001334	ENSOCUP00000003366	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRCA2	ENSOCUP00000001334	ENSOCUP00000014514	BRCA1 associated RING domain 1.	BRCA2 DNA repair associated.	0.994
BARD1	BRIP1	ENSOCUP00000001334	ENSOCUP00000005779	BRCA1 associated RING domain 1.	BRCA1 interacting protein C-terminal helicase 1.	0.993
BARD1	MRE11	ENSOCUP00000001334	ENSOCUP00000012812	BRCA1 associated RING domain 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.992
BARD1	NBN	ENSOCUP00000001334	ENSOCUP00000029655	BRCA1 associated RING domain 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.987
BARD1	RAD50	ENSOCUP00000001334	ENSOCUP00000016215	BRCA1 associated RING domain 1.	Zinc-hook domain-containing protein.	0.986
BARD1	RAD51	ENSOCUP00000001334	ENSOCUP00000014527	BRCA1 associated RING domain 1.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...]	0.983
BARD1	RBBP8	ENSOCUP00000001334	ENSOCUP00000006341	BRCA1 associated RING domain 1.	CtIP_N domain-containing protein.	0.976
BARD1	TOPBP1	ENSOCUP00000001334	ENSOCUP00000010983	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.991
BRCA1	BAP1	ENSOCUP00000003366	ENSOCUP00000041822	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated protein 1.	0.896
BRCA1	BARD1	ENSOCUP00000003366	ENSOCUP00000001334	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	BRCA2	ENSOCUP00000003366	ENSOCUP00000014514	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA2 DNA repair associated.	0.999
BRCA1	BRIP1	ENSOCUP00000003366	ENSOCUP00000005779	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 interacting protein C-terminal helicase 1.	0.998
BRCA1	MRE11	ENSOCUP00000003366	ENSOCUP00000012812	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.992