node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCZ1 | RAB7A | ENSOCUP00000030822 | ENSOCUP00000001409 | Uncharacterized protein. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.931 |
CCZ1 | RAB7B | ENSOCUP00000030822 | ENSOCUP00000029371 | Uncharacterized protein. | Uncharacterized protein. | 0.953 |
CCZ1 | TBC1D15 | ENSOCUP00000030822 | ENSOCUP00000013443 | Uncharacterized protein. | TBC1 domain family member 15. | 0.584 |
CHM | RAB7A | ENSOCUP00000011031 | ENSOCUP00000001409 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.888 |
CHM | RAB7B | ENSOCUP00000011031 | ENSOCUP00000029371 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | Uncharacterized protein. | 0.799 |
DYNC1I2 | DYNC1LI2 | ENSOCUP00000034440 | ENSOCUP00000003982 | Dynein cytoplasmic 1 intermediate chain 2. | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | 0.999 |
DYNC1I2 | DYNC2H1 | ENSOCUP00000034440 | ENSOCUP00000047035 | Dynein cytoplasmic 1 intermediate chain 2. | Dynein cytoplasmic 2 heavy chain 1. | 0.975 |
DYNC1I2 | RAB7A | ENSOCUP00000034440 | ENSOCUP00000001409 | Dynein cytoplasmic 1 intermediate chain 2. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.839 |
DYNC1I2 | RAB7B | ENSOCUP00000034440 | ENSOCUP00000029371 | Dynein cytoplasmic 1 intermediate chain 2. | Uncharacterized protein. | 0.800 |
DYNC1LI2 | DYNC1I2 | ENSOCUP00000003982 | ENSOCUP00000034440 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | Dynein cytoplasmic 1 intermediate chain 2. | 0.999 |
DYNC1LI2 | DYNC2H1 | ENSOCUP00000003982 | ENSOCUP00000047035 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | Dynein cytoplasmic 2 heavy chain 1. | 0.979 |
DYNC1LI2 | RAB7A | ENSOCUP00000003982 | ENSOCUP00000001409 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.890 |
DYNC1LI2 | RAB7B | ENSOCUP00000003982 | ENSOCUP00000029371 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | Uncharacterized protein. | 0.808 |
DYNC2H1 | DYNC1I2 | ENSOCUP00000047035 | ENSOCUP00000034440 | Dynein cytoplasmic 2 heavy chain 1. | Dynein cytoplasmic 1 intermediate chain 2. | 0.975 |
DYNC2H1 | DYNC1LI2 | ENSOCUP00000047035 | ENSOCUP00000003982 | Dynein cytoplasmic 2 heavy chain 1. | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | 0.979 |
DYNC2H1 | RAB7A | ENSOCUP00000047035 | ENSOCUP00000001409 | Dynein cytoplasmic 2 heavy chain 1. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.831 |
DYNC2H1 | RAB7B | ENSOCUP00000047035 | ENSOCUP00000029371 | Dynein cytoplasmic 2 heavy chain 1. | Uncharacterized protein. | 0.802 |
FYCO1 | OSBPL1A | ENSOCUP00000003724 | ENSOCUP00000007256 | FYVE and coiled-coil domain containing 1. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.415 |
FYCO1 | RAB7A | ENSOCUP00000003724 | ENSOCUP00000001409 | FYVE and coiled-coil domain containing 1. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.953 |
FYCO1 | RAB7B | ENSOCUP00000003724 | ENSOCUP00000029371 | FYVE and coiled-coil domain containing 1. | Uncharacterized protein. | 0.911 |