RAB7A protein (Oryctolagus cuniculus) - STRING interaction network

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RAB7A

Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa)

Predicted Functional Partners:

RILP

0.980

CCZ1

0.966

PLEKHM1

0.960

MON1A

0.953

VPS11

0.941

RAB2A-2

0.929

RAB1A

0.922

CHM

0.921

VPS39

0.920

TBC1D15

0.919

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCZ1	CHM	ENSOCUP00000030822	ENSOCUP00000011031	Uncharacterized protein.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.626
CCZ1	MON1A	ENSOCUP00000030822	ENSOCUP00000007566	Uncharacterized protein.	MON1 homolog A, secretory trafficking associated.	0.995
CCZ1	PLEKHM1	ENSOCUP00000030822	ENSOCUP00000007396	Uncharacterized protein.	Pleckstrin homology and RUN domain containing M1.	0.526
CCZ1	RAB1A	ENSOCUP00000030822	ENSOCUP00000014605	Uncharacterized protein.	RAB1A, member RAS oncogene family.	0.409
CCZ1	RAB7A	ENSOCUP00000030822	ENSOCUP00000001409	Uncharacterized protein.	Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...]	0.966
CCZ1	RILP	ENSOCUP00000030822	ENSOCUP00000000067	Uncharacterized protein.	Rab interacting lysosomal protein.	0.480
CCZ1	TBC1D15	ENSOCUP00000030822	ENSOCUP00000013443	Uncharacterized protein.	TBC1 domain family member 15.	0.725
CCZ1	VPS11	ENSOCUP00000030822	ENSOCUP00000016191	Uncharacterized protein.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.946
CCZ1	VPS39	ENSOCUP00000030822	ENSOCUP00000023983	Uncharacterized protein.	VPS39 subunit of HOPS complex.	0.951
CHM	CCZ1	ENSOCUP00000011031	ENSOCUP00000030822	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Uncharacterized protein.	0.626
CHM	MON1A	ENSOCUP00000011031	ENSOCUP00000007566	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	MON1 homolog A, secretory trafficking associated.	0.434
CHM	RAB1A	ENSOCUP00000011031	ENSOCUP00000014605	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB1A, member RAS oncogene family.	0.953
CHM	RAB2A-2	ENSOCUP00000011031	ENSOCUP00000047628	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Ras-related protein Rab-2A.	0.615
CHM	RAB7A	ENSOCUP00000011031	ENSOCUP00000001409	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...]	0.921
MON1A	CCZ1	ENSOCUP00000007566	ENSOCUP00000030822	MON1 homolog A, secretory trafficking associated.	Uncharacterized protein.	0.995
MON1A	CHM	ENSOCUP00000007566	ENSOCUP00000011031	MON1 homolog A, secretory trafficking associated.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.434
MON1A	RAB7A	ENSOCUP00000007566	ENSOCUP00000001409	MON1 homolog A, secretory trafficking associated.	Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...]	0.953
MON1A	RILP	ENSOCUP00000007566	ENSOCUP00000000067	MON1 homolog A, secretory trafficking associated.	Rab interacting lysosomal protein.	0.425
MON1A	TBC1D15	ENSOCUP00000007566	ENSOCUP00000013443	MON1 homolog A, secretory trafficking associated.	TBC1 domain family member 15.	0.813
MON1A	VPS11	ENSOCUP00000007566	ENSOCUP00000016191	MON1 homolog A, secretory trafficking associated.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.729

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