node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOB | CETP | ENSOCUP00000004631 | ENSOCUP00000011306 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). | 0.978 |
APOB | ENSOCUP00000037325 | ENSOCUP00000004631 | ENSOCUP00000037325 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.456 |
APOB | LIPC | ENSOCUP00000004631 | ENSOCUP00000001411 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). | 0.977 |
APOB | LIPF | ENSOCUP00000004631 | ENSOCUP00000010744 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.472 |
APOB | LPL | ENSOCUP00000004631 | ENSOCUP00000027265 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.923 |
APOB | PNLIPRP1 | ENSOCUP00000004631 | ENSOCUP00000007072 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.458 |
APOB | PNLIPRP2 | ENSOCUP00000004631 | ENSOCUP00000048398 | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.448 |
CETP | APOB | ENSOCUP00000011306 | ENSOCUP00000004631 | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 0.978 |
CETP | LIPC | ENSOCUP00000011306 | ENSOCUP00000001411 | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). | Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). | 0.910 |
CETP | LPL | ENSOCUP00000011306 | ENSOCUP00000027265 | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.851 |
ENSOCUP00000037325 | APOB | ENSOCUP00000037325 | ENSOCUP00000004631 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | 0.456 |
ENSOCUP00000037325 | G1THC3_RABIT | ENSOCUP00000037325 | ENSOCUP00000016329 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | PNPLA domain-containing protein. | 0.905 |
ENSOCUP00000037325 | LIPC | ENSOCUP00000037325 | ENSOCUP00000001411 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). | 0.940 |
ENSOCUP00000037325 | LIPF | ENSOCUP00000037325 | ENSOCUP00000010744 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.915 |
ENSOCUP00000037325 | LPL | ENSOCUP00000037325 | ENSOCUP00000027265 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.917 |
ENSOCUP00000037325 | MGLL | ENSOCUP00000037325 | ENSOCUP00000034747 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Uncharacterized protein. | 0.913 |
ENSOCUP00000037325 | PLPP4 | ENSOCUP00000037325 | ENSOCUP00000029716 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | acidPPc domain-containing protein. | 0.903 |
ENSOCUP00000037325 | PNLIPRP1 | ENSOCUP00000037325 | ENSOCUP00000007072 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
ENSOCUP00000037325 | PNLIPRP2 | ENSOCUP00000037325 | ENSOCUP00000048398 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.903 |
G1THC3_RABIT | ENSOCUP00000037325 | ENSOCUP00000016329 | ENSOCUP00000037325 | PNPLA domain-containing protein. | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. | 0.905 |