Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PDIA4Protein disulfide-isomerase. (646 aa)    
Predicted Functional Partners:
HSPA5
Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.
   
 0.995
PDIA6
Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.
   
0.992
HSP90B1
Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
   
 0.991
CALR3
Calreticulin.
   
 0.986
HYOU1
Hypoxia up-regulated 1.
   
 0.979
ERO1A
Endoplasmic reticulum oxidoreductase 1 alpha.
   
 0.970
PDIA3
Protein disulfide-isomerase.
  
 
0.965
ERO1B
Endoplasmic reticulum oxidoreductase 1 beta.
   
 0.961
TXNDC5
Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family.
   
0.960
CALR
Calreticulin.
   
 0.937
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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