IL22 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

IL22

Interleukin 22. (187 aa)

Predicted Functional Partners:

IL22RA1

0.997

IL22RA2

0.996

IL10

0.986

IL26

0.977

IL10RB

0.973

IL19

0.954

IL17A

0.943

TP53BP2

0.941

IL20RA

0.937

TYK2

0.925

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RB	ENSOCUP00000019534	ENSOCUP00000001025	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.966
IL10	IL17A	ENSOCUP00000019534	ENSOCUP00000003688	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 17A.	0.941
IL10	IL19	ENSOCUP00000019534	ENSOCUP00000012271	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 19.	0.945
IL10	IL20RA	ENSOCUP00000019534	ENSOCUP00000013480	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 20 receptor subunit alpha.	0.918
IL10	IL22	ENSOCUP00000019534	ENSOCUP00000001423	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.986
IL10	IL22RA1	ENSOCUP00000019534	ENSOCUP00000005829	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.926
IL10	IL22RA2	ENSOCUP00000019534	ENSOCUP00000022104	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 2.	0.866
IL10	IL26	ENSOCUP00000019534	ENSOCUP00000000432	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 26.	0.944
IL10	TP53BP2	ENSOCUP00000019534	ENSOCUP00000003994	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tumor protein p53 binding protein 2.	0.922
IL10	TYK2	ENSOCUP00000019534	ENSOCUP00000036146	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Non-specific protein-tyrosine kinase.	0.943
IL10RB	IL10	ENSOCUP00000001025	ENSOCUP00000019534	Interleukin 10 receptor subunit beta.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.966
IL10RB	IL19	ENSOCUP00000001025	ENSOCUP00000012271	Interleukin 10 receptor subunit beta.	Interleukin 19.	0.817
IL10RB	IL20RA	ENSOCUP00000001025	ENSOCUP00000013480	Interleukin 10 receptor subunit beta.	Interleukin 20 receptor subunit alpha.	0.830
IL10RB	IL22	ENSOCUP00000001025	ENSOCUP00000001423	Interleukin 10 receptor subunit beta.	Interleukin 22.	0.973
IL10RB	IL22RA1	ENSOCUP00000001025	ENSOCUP00000005829	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 1.	0.963
IL10RB	IL22RA2	ENSOCUP00000001025	ENSOCUP00000022104	Interleukin 10 receptor subunit beta.	Interleukin 22 receptor subunit alpha 2.	0.880
IL10RB	IL26	ENSOCUP00000001025	ENSOCUP00000000432	Interleukin 10 receptor subunit beta.	Interleukin 26.	0.925
IL10RB	TYK2	ENSOCUP00000001025	ENSOCUP00000036146	Interleukin 10 receptor subunit beta.	Non-specific protein-tyrosine kinase.	0.919
IL17A	IL10	ENSOCUP00000003688	ENSOCUP00000019534	Interleukin 17A.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.941
IL17A	IL19	ENSOCUP00000003688	ENSOCUP00000012271	Interleukin 17A.	Interleukin 19.	0.457