Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
KSR2Kinase suppressor of ras 2. (950 aa)    
Predicted Functional Partners:
BRAP
BRCA1 associated protein.
    
 0.942
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]
   
 0.904
KSR1
Kinase suppressor of ras 1.
     
  0.851
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
    
 0.794
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
 0.794
MAP2K5
Mitogen-activated protein kinase kinase 5.
   
 0.791
CNKSR2
Connector enhancer of kinase suppressor of Ras 2.
    
 0.789
METTL6
Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family.
    
 
 0.758
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.738
CD209
C-type lectin domain-containing protein.
    
 0.727
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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