G1SG29_RABIT protein (Oryctolagus cuniculus)

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Score

G1SG29_RABIT

Skp1_POZ domain-containing protein. (72 aa)

Predicted Functional Partners:

UBXN7

0.986

LEO1

0.946

VHL

0.902

CUL2

0.889

CUL5

0.884

HIF1A

0.875

ENSOCUP00000035728

0.873

SOCS4

0.865

SOCS2

0.860

NEDD8

0.851

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL2	CUL5	ENSOCUP00000012675	ENSOCUP00000009389	Cullin 2; Belongs to the cullin family.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.927
CUL2	ENSOCUP00000035728	ENSOCUP00000012675	ENSOCUP00000035728	Cullin 2; Belongs to the cullin family.	Zf-rbx1 domain-containing protein.	0.999
CUL2	G1SG29_RABIT	ENSOCUP00000012675	ENSOCUP00000001516	Cullin 2; Belongs to the cullin family.	Skp1_POZ domain-containing protein.	0.889
CUL2	HIF1A	ENSOCUP00000012675	ENSOCUP00000041090	Cullin 2; Belongs to the cullin family.	Uncharacterized protein.	0.992
CUL2	NEDD8	ENSOCUP00000012675	ENSOCUP00000002526	Cullin 2; Belongs to the cullin family.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.994
CUL2	SOCS2	ENSOCUP00000012675	ENSOCUP00000001084	Cullin 2; Belongs to the cullin family.	Suppressor of cytokine signaling 2.	0.557
CUL2	SOCS4	ENSOCUP00000012675	ENSOCUP00000003465	Cullin 2; Belongs to the cullin family.	Suppressor of cytokine signaling 4.	0.657
CUL2	UBXN7	ENSOCUP00000012675	ENSOCUP00000010586	Cullin 2; Belongs to the cullin family.	UBX domain-containing protein.	0.995
CUL2	VHL	ENSOCUP00000012675	ENSOCUP00000027793	Cullin 2; Belongs to the cullin family.	Uncharacterized protein.	0.994
CUL5	CUL2	ENSOCUP00000009389	ENSOCUP00000012675	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Cullin 2; Belongs to the cullin family.	0.927
CUL5	ENSOCUP00000035728	ENSOCUP00000009389	ENSOCUP00000035728	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Zf-rbx1 domain-containing protein.	0.997
CUL5	G1SG29_RABIT	ENSOCUP00000009389	ENSOCUP00000001516	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Skp1_POZ domain-containing protein.	0.884
CUL5	NEDD8	ENSOCUP00000009389	ENSOCUP00000002526	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.994
CUL5	SOCS2	ENSOCUP00000009389	ENSOCUP00000001084	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 2.	0.983
CUL5	SOCS4	ENSOCUP00000009389	ENSOCUP00000003465	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 4.	0.943
CUL5	VHL	ENSOCUP00000009389	ENSOCUP00000027793	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Uncharacterized protein.	0.594
ENSOCUP00000035728	CUL2	ENSOCUP00000035728	ENSOCUP00000012675	Zf-rbx1 domain-containing protein.	Cullin 2; Belongs to the cullin family.	0.999
ENSOCUP00000035728	CUL5	ENSOCUP00000035728	ENSOCUP00000009389	Zf-rbx1 domain-containing protein.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.997
ENSOCUP00000035728	G1SG29_RABIT	ENSOCUP00000035728	ENSOCUP00000001516	Zf-rbx1 domain-containing protein.	Skp1_POZ domain-containing protein.	0.873
ENSOCUP00000035728	HIF1A	ENSOCUP00000035728	ENSOCUP00000041090	Zf-rbx1 domain-containing protein.	Uncharacterized protein.	0.613