REST protein (Oryctolagus cuniculus) - STRING interaction network

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Score

REST

RE1 silencing transcription factor. (930 aa)

Predicted Functional Partners:

RCOR1

0.987

SIN3A

0.957

HDAC2

0.952

HDAC1

0.951

KDM1A

0.928

BTRC

0.924

HTT

0.917

RCOR2

0.916

ENSOCUP00000034777

0.910

RCOR3

0.886

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	REST	ENSOCUP00000049583	ENSOCUP00000001526	Beta-transducin repeat containing E3 ubiquitin protein ligase.	RE1 silencing transcription factor.	0.924
ENSOCUP00000034777	HDAC2	ENSOCUP00000034777	ENSOCUP00000040151	Uncharacterized protein.	Histone deacetylase 2.	0.991
ENSOCUP00000034777	KDM1A	ENSOCUP00000034777	ENSOCUP00000001013	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.911
ENSOCUP00000034777	RCOR1	ENSOCUP00000034777	ENSOCUP00000043168	Uncharacterized protein.	REST corepressor 1.	0.965
ENSOCUP00000034777	RCOR2	ENSOCUP00000034777	ENSOCUP00000025542	Uncharacterized protein.	REST corepressor 2.	0.731
ENSOCUP00000034777	RCOR3	ENSOCUP00000034777	ENSOCUP00000007879	Uncharacterized protein.	REST corepressor 3.	0.859
ENSOCUP00000034777	REST	ENSOCUP00000034777	ENSOCUP00000001526	Uncharacterized protein.	RE1 silencing transcription factor.	0.910
ENSOCUP00000034777	SIN3A	ENSOCUP00000034777	ENSOCUP00000034155	Uncharacterized protein.	SIN3 transcription regulator family member A.	0.951
HDAC1	HDAC2	ENSOCUP00000037903	ENSOCUP00000040151	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 2.	0.998
HDAC1	KDM1A	ENSOCUP00000037903	ENSOCUP00000001013	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.953
HDAC1	RCOR1	ENSOCUP00000037903	ENSOCUP00000043168	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	REST corepressor 1.	0.972
HDAC1	RCOR2	ENSOCUP00000037903	ENSOCUP00000025542	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	REST corepressor 2.	0.794
HDAC1	RCOR3	ENSOCUP00000037903	ENSOCUP00000007879	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	REST corepressor 3.	0.914
HDAC1	REST	ENSOCUP00000037903	ENSOCUP00000001526	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	RE1 silencing transcription factor.	0.951
HDAC1	SIN3A	ENSOCUP00000037903	ENSOCUP00000034155	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	SIN3 transcription regulator family member A.	0.991
HDAC2	ENSOCUP00000034777	ENSOCUP00000040151	ENSOCUP00000034777	Histone deacetylase 2.	Uncharacterized protein.	0.991
HDAC2	HDAC1	ENSOCUP00000040151	ENSOCUP00000037903	Histone deacetylase 2.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.998
HDAC2	KDM1A	ENSOCUP00000040151	ENSOCUP00000001013	Histone deacetylase 2.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.984
HDAC2	RCOR1	ENSOCUP00000040151	ENSOCUP00000043168	Histone deacetylase 2.	REST corepressor 1.	0.994
HDAC2	RCOR2	ENSOCUP00000040151	ENSOCUP00000025542	Histone deacetylase 2.	REST corepressor 2.	0.857