RNF169 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RNF169

Ring finger protein 169. (710 aa)

Predicted Functional Partners:

DYRK1A

0.955

DCAF7

0.916

RNF8

0.901

USP7

0.875

BRCA1

0.855

DYRK1B

0.839

RAD18

0.819

ENSOCUP00000044498

0.815

FBXO38

0.813

TP53BP1

0.813

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	RAD18	ENSOCUP00000003366	ENSOCUP00000029275	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Uncharacterized protein.	0.943
BRCA1	RNF169	ENSOCUP00000003366	ENSOCUP00000001537	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ring finger protein 169.	0.855
BRCA1	RNF8	ENSOCUP00000003366	ENSOCUP00000036851	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ring finger protein 8.	0.906
BRCA1	TP53BP1	ENSOCUP00000003366	ENSOCUP00000048342	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tumor protein p53 binding protein 1.	0.992
DCAF7	DYRK1A	ENSOCUP00000013632	ENSOCUP00000032789	DDB1 and CUL4 associated factor 7.	Dual-specificity tyrosine-phosphorylation-regulated kinase 1A.	0.984
DCAF7	DYRK1B	ENSOCUP00000013632	ENSOCUP00000023813	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.981
DCAF7	RNF169	ENSOCUP00000013632	ENSOCUP00000001537	DDB1 and CUL4 associated factor 7.	Ring finger protein 169.	0.916
DYRK1A	DCAF7	ENSOCUP00000032789	ENSOCUP00000013632	Dual-specificity tyrosine-phosphorylation-regulated kinase 1A.	DDB1 and CUL4 associated factor 7.	0.984
DYRK1A	DYRK1B	ENSOCUP00000032789	ENSOCUP00000023813	Dual-specificity tyrosine-phosphorylation-regulated kinase 1A.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.882
DYRK1A	RNF169	ENSOCUP00000032789	ENSOCUP00000001537	Dual-specificity tyrosine-phosphorylation-regulated kinase 1A.	Ring finger protein 169.	0.955
DYRK1B	DCAF7	ENSOCUP00000023813	ENSOCUP00000013632	Dual specificity tyrosine phosphorylation regulated kinase 1B.	DDB1 and CUL4 associated factor 7.	0.981
DYRK1B	DYRK1A	ENSOCUP00000023813	ENSOCUP00000032789	Dual specificity tyrosine phosphorylation regulated kinase 1B.	Dual-specificity tyrosine-phosphorylation-regulated kinase 1A.	0.882
DYRK1B	RNF169	ENSOCUP00000023813	ENSOCUP00000001537	Dual specificity tyrosine phosphorylation regulated kinase 1B.	Ring finger protein 169.	0.839
ENSOCUP00000044498	RAD18	ENSOCUP00000044498	ENSOCUP00000029275	Ribosomal_L40e domain-containing protein.	Uncharacterized protein.	0.834
ENSOCUP00000044498	RNF169	ENSOCUP00000044498	ENSOCUP00000001537	Ribosomal_L40e domain-containing protein.	Ring finger protein 169.	0.815
ENSOCUP00000044498	RNF8	ENSOCUP00000044498	ENSOCUP00000036851	Ribosomal_L40e domain-containing protein.	Ring finger protein 8.	0.400
ENSOCUP00000044498	TP53BP1	ENSOCUP00000044498	ENSOCUP00000048342	Ribosomal_L40e domain-containing protein.	Tumor protein p53 binding protein 1.	0.861
ENSOCUP00000044498	USP7	ENSOCUP00000044498	ENSOCUP00000026870	Ribosomal_L40e domain-containing protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.857
FBXO38	RNF169	ENSOCUP00000014862	ENSOCUP00000001537	F-box protein 38.	Ring finger protein 169.	0.813
FBXO38	USP7	ENSOCUP00000014862	ENSOCUP00000026870	F-box protein 38.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.903