ETAA1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

ETAA1

ETAA1 activator of ATR kinase. (872 aa)

Predicted Functional Partners:

ATRIP

0.912

RPA1

0.816

TOPBP1

0.815

RPA2

0.800

ATR

0.798

BRCA1

0.797

RPAIN

0.723

RAD17

0.720

WDR92

0.681

TUBGCP5

0.665

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATR	ATRIP	ENSOCUP00000001626	ENSOCUP00000004508	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ATR interacting protein.	0.998
ATR	BRCA1	ENSOCUP00000001626	ENSOCUP00000003366	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.993
ATR	ETAA1	ENSOCUP00000001626	ENSOCUP00000001556	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ETAA1 activator of ATR kinase.	0.798
ATR	RAD17	ENSOCUP00000001626	ENSOCUP00000037201	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	RAD17 checkpoint clamp loader component.	0.971
ATR	RPA1	ENSOCUP00000001626	ENSOCUP00000042935	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.923
ATR	RPA2	ENSOCUP00000001626	ENSOCUP00000013917	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A2.	0.894
ATR	TOPBP1	ENSOCUP00000001626	ENSOCUP00000010983	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	DNA topoisomerase II binding protein 1.	0.984
ATRIP	ATR	ENSOCUP00000004508	ENSOCUP00000001626	ATR interacting protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
ATRIP	BRCA1	ENSOCUP00000004508	ENSOCUP00000003366	ATR interacting protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.963
ATRIP	ETAA1	ENSOCUP00000004508	ENSOCUP00000001556	ATR interacting protein.	ETAA1 activator of ATR kinase.	0.912
ATRIP	RAD17	ENSOCUP00000004508	ENSOCUP00000037201	ATR interacting protein.	RAD17 checkpoint clamp loader component.	0.965
ATRIP	RPA1	ENSOCUP00000004508	ENSOCUP00000042935	ATR interacting protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.984
ATRIP	RPA2	ENSOCUP00000004508	ENSOCUP00000013917	ATR interacting protein.	Replication protein A2.	0.914
ATRIP	TOPBP1	ENSOCUP00000004508	ENSOCUP00000010983	ATR interacting protein.	DNA topoisomerase II binding protein 1.	0.992
BRCA1	ATR	ENSOCUP00000003366	ENSOCUP00000001626	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.993
BRCA1	ATRIP	ENSOCUP00000003366	ENSOCUP00000004508	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR interacting protein.	0.963
BRCA1	ETAA1	ENSOCUP00000003366	ENSOCUP00000001556	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ETAA1 activator of ATR kinase.	0.797
BRCA1	RAD17	ENSOCUP00000003366	ENSOCUP00000037201	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAD17 checkpoint clamp loader component.	0.808
BRCA1	RPA1	ENSOCUP00000003366	ENSOCUP00000042935	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.944
BRCA1	RPA2	ENSOCUP00000003366	ENSOCUP00000013917	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Replication protein A2.	0.731