SLC12A2 protein (Oryctolagus cuniculus) - STRING interaction network

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SLC12A2

Solute carrier family 12 member 2. (1127 aa)

Predicted Functional Partners:

KIAA1324

0.976

STK39

0.939

KCNQ1

0.896

WNK1

0.855

WNK3

0.848

WNK4

0.819

SLC4A2

0.805

SLC4A4

0.764

CFTR

0.761

SLC9A1

0.710

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFTR	KCNQ1	ENSOCUP00000034709	ENSOCUP00000040140	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...]	0.449
CFTR	SLC12A2	ENSOCUP00000034709	ENSOCUP00000001558	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Solute carrier family 12 member 2.	0.761
CFTR	SLC4A2	ENSOCUP00000034709	ENSOCUP00000049524	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family.	0.617
CFTR	SLC4A4	ENSOCUP00000034709	ENSOCUP00000047986	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.	0.697
CFTR	SLC9A1	ENSOCUP00000034709	ENSOCUP00000022999	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.548
KCNQ1	CFTR	ENSOCUP00000040140	ENSOCUP00000034709	Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...]	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.449
KCNQ1	SLC12A2	ENSOCUP00000040140	ENSOCUP00000001558	Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...]	Solute carrier family 12 member 2.	0.896
KIAA1324	SLC12A2	ENSOCUP00000007437	ENSOCUP00000001558	KIAA1324.	Solute carrier family 12 member 2.	0.976
SLC12A2	CFTR	ENSOCUP00000001558	ENSOCUP00000034709	Solute carrier family 12 member 2.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.761
SLC12A2	KCNQ1	ENSOCUP00000001558	ENSOCUP00000040140	Solute carrier family 12 member 2.	Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...]	0.896
SLC12A2	KIAA1324	ENSOCUP00000001558	ENSOCUP00000007437	Solute carrier family 12 member 2.	KIAA1324.	0.976
SLC12A2	SLC4A2	ENSOCUP00000001558	ENSOCUP00000049524	Solute carrier family 12 member 2.	Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family.	0.805
SLC12A2	SLC4A4	ENSOCUP00000001558	ENSOCUP00000047986	Solute carrier family 12 member 2.	Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.	0.764
SLC12A2	SLC9A1	ENSOCUP00000001558	ENSOCUP00000022999	Solute carrier family 12 member 2.	Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.710
SLC12A2	STK39	ENSOCUP00000001558	ENSOCUP00000015356	Solute carrier family 12 member 2.	Serine/threonine kinase 39.	0.939
SLC12A2	WNK1	ENSOCUP00000001558	ENSOCUP00000033996	Solute carrier family 12 member 2.	WNK lysine deficient protein kinase 1.	0.855
SLC12A2	WNK3	ENSOCUP00000001558	ENSOCUP00000009988	Solute carrier family 12 member 2.	WNK lysine deficient protein kinase 3.	0.848
SLC12A2	WNK4	ENSOCUP00000001558	ENSOCUP00000013708	Solute carrier family 12 member 2.	WNK lysine deficient protein kinase 4.	0.819
SLC4A2	CFTR	ENSOCUP00000049524	ENSOCUP00000034709	Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.617
SLC4A2	SLC12A2	ENSOCUP00000049524	ENSOCUP00000001558	Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family.	Solute carrier family 12 member 2.	0.805