| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP4 | CFTR | ENSOCUP00000007625 | ENSOCUP00000034709 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.593 |
| AQP4 | SLC12A2 | ENSOCUP00000007625 | ENSOCUP00000001558 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Solute carrier family 12 member 2. | 0.699 |
| AQP4 | SLC4A4 | ENSOCUP00000007625 | ENSOCUP00000047986 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. | 0.431 |
| AQP4 | SLC9A1 | ENSOCUP00000007625 | ENSOCUP00000022999 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.401 |
| CFTR | AQP4 | ENSOCUP00000034709 | ENSOCUP00000007625 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.593 |
| CFTR | SLC12A2 | ENSOCUP00000034709 | ENSOCUP00000001558 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Solute carrier family 12 member 2. | 0.774 |
| CFTR | SLC26A6 | ENSOCUP00000034709 | ENSOCUP00000000544 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Solute carrier family 26 member 6. | 0.806 |
| CFTR | SLC4A2 | ENSOCUP00000034709 | ENSOCUP00000049524 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family. | 0.612 |
| CFTR | SLC4A4 | ENSOCUP00000034709 | ENSOCUP00000047986 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. | 0.679 |
| CFTR | SLC9A1 | ENSOCUP00000034709 | ENSOCUP00000022999 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.593 |
| CFTR | SLC9A3 | ENSOCUP00000034709 | ENSOCUP00000046707 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.791 |
| SLC12A2 | AQP4 | ENSOCUP00000001558 | ENSOCUP00000007625 | Solute carrier family 12 member 2. | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.699 |
| SLC12A2 | CFTR | ENSOCUP00000001558 | ENSOCUP00000034709 | Solute carrier family 12 member 2. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.774 |
| SLC12A2 | SLC26A6 | ENSOCUP00000001558 | ENSOCUP00000000544 | Solute carrier family 12 member 2. | Solute carrier family 26 member 6. | 0.694 |
| SLC12A2 | SLC4A2 | ENSOCUP00000001558 | ENSOCUP00000049524 | Solute carrier family 12 member 2. | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family. | 0.803 |
| SLC12A2 | SLC4A4 | ENSOCUP00000001558 | ENSOCUP00000047986 | Solute carrier family 12 member 2. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. | 0.741 |
| SLC12A2 | SLC9A1 | ENSOCUP00000001558 | ENSOCUP00000022999 | Solute carrier family 12 member 2. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.719 |
| SLC12A2 | SLC9A3 | ENSOCUP00000001558 | ENSOCUP00000046707 | Solute carrier family 12 member 2. | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.703 |
| SLC12A2 | WNK1 | ENSOCUP00000001558 | ENSOCUP00000033996 | Solute carrier family 12 member 2. | WNK lysine deficient protein kinase 1. | 0.854 |
| SLC12A2 | WNK3 | ENSOCUP00000001558 | ENSOCUP00000009988 | Solute carrier family 12 member 2. | WNK lysine deficient protein kinase 3. | 0.852 |