| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCR7 | CD4 | ENSOCUP00000017477 | ENSOCUP00000030708 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.919 |
| CCR7 | CD40LG | ENSOCUP00000017477 | ENSOCUP00000003395 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | 0.757 |
| CCR7 | CTLA4 | ENSOCUP00000017477 | ENSOCUP00000017677 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. | 0.817 |
| CCR7 | CXCR5 | ENSOCUP00000017477 | ENSOCUP00000018534 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. | 0.593 |
| CCR7 | ICOS | ENSOCUP00000017477 | ENSOCUP00000001599 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Inducible T cell costimulator. | 0.891 |
| CD4 | CCR7 | ENSOCUP00000030708 | ENSOCUP00000017477 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.919 |
| CD4 | CD40LG | ENSOCUP00000030708 | ENSOCUP00000003395 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | 0.925 |
| CD4 | CTLA4 | ENSOCUP00000030708 | ENSOCUP00000017677 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. | 0.932 |
| CD4 | CXCR5 | ENSOCUP00000030708 | ENSOCUP00000018534 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. | 0.885 |
| CD4 | ICOS | ENSOCUP00000030708 | ENSOCUP00000001599 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Inducible T cell costimulator. | 0.914 |
| CD4 | PIK3CA | ENSOCUP00000030708 | ENSOCUP00000026298 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.598 |
| CD4 | PIK3CB | ENSOCUP00000030708 | ENSOCUP00000004241 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.501 |
| CD4 | PIK3CD | ENSOCUP00000030708 | ENSOCUP00000021004 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.501 |
| CD40LG | CCR7 | ENSOCUP00000003395 | ENSOCUP00000017477 | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.757 |
| CD40LG | CD4 | ENSOCUP00000003395 | ENSOCUP00000030708 | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.925 |
| CD40LG | CTLA4 | ENSOCUP00000003395 | ENSOCUP00000017677 | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. | 0.823 |
| CD40LG | CXCR5 | ENSOCUP00000003395 | ENSOCUP00000018534 | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. | 0.828 |
| CD40LG | ICOS | ENSOCUP00000003395 | ENSOCUP00000001599 | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. | Inducible T cell costimulator. | 0.984 |
| CTLA4 | CCR7 | ENSOCUP00000017677 | ENSOCUP00000017477 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.817 |
| CTLA4 | CD4 | ENSOCUP00000017677 | ENSOCUP00000030708 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.932 |
