GSDMD protein (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

GSDMD

Gasdermin D. (471 aa)

Predicted Functional Partners:

CASP1

0.999

CASP4

0.997

LOC100358658

0.984

NLRP3

0.980

IL1B

0.930

IL18

0.910

CASP3

0.882

GSDME

0.862

CASP8

0.840

PYCARD

0.829

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CASP4	ENSOCUP00000000956	ENSOCUP00000006490	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.590
CASP1	CASP8	ENSOCUP00000000956	ENSOCUP00000049942	Uncharacterized protein; Belongs to the peptidase C14A family.	DED domain-containing protein.	0.991
CASP1	GSDMD	ENSOCUP00000000956	ENSOCUP00000001621	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin D.	0.999
CASP1	GSDME	ENSOCUP00000000956	ENSOCUP00000045404	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin E.	0.831
CASP1	IL18	ENSOCUP00000000956	ENSOCUP00000004555	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.998
CASP1	IL1B	ENSOCUP00000000956	ENSOCUP00000021869	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.999
CASP1	NLRP3	ENSOCUP00000000956	ENSOCUP00000004733	Uncharacterized protein; Belongs to the peptidase C14A family.	NLR family pyrin domain containing 3.	0.992
CASP1	PYCARD	ENSOCUP00000000956	ENSOCUP00000003881	Uncharacterized protein; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.999
CASP3	CASP8	ENSOCUP00000036614	ENSOCUP00000049942	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	DED domain-containing protein.	0.999
CASP3	GSDMD	ENSOCUP00000036614	ENSOCUP00000001621	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Gasdermin D.	0.882
CASP3	GSDME	ENSOCUP00000036614	ENSOCUP00000045404	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Gasdermin E.	0.884
CASP3	IL18	ENSOCUP00000036614	ENSOCUP00000004555	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Uncharacterized protein.	0.724
CASP3	IL1B	ENSOCUP00000036614	ENSOCUP00000021869	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.905
CASP3	LOC100358658	ENSOCUP00000036614	ENSOCUP00000026479	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.402
CASP4	CASP1	ENSOCUP00000006490	ENSOCUP00000000956	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.590
CASP4	CASP8	ENSOCUP00000006490	ENSOCUP00000049942	Uncharacterized protein; Belongs to the peptidase C14A family.	DED domain-containing protein.	0.698
CASP4	GSDMD	ENSOCUP00000006490	ENSOCUP00000001621	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin D.	0.997
CASP4	GSDME	ENSOCUP00000006490	ENSOCUP00000045404	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin E.	0.638
CASP4	IL18	ENSOCUP00000006490	ENSOCUP00000004555	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.628
CASP4	IL1B	ENSOCUP00000006490	ENSOCUP00000021869	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.811