| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACKR3 | CCL21 | ENSOCUP00000009382 | ENSOCUP00000020728 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine ligand 21. | 0.609 |
| ACKR3 | CCL5 | ENSOCUP00000009382 | ENSOCUP00000002470 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine. | 0.462 |
| ACKR3 | CX3CL1 | ENSOCUP00000009382 | ENSOCUP00000006470 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-X3-C motif chemokine ligand 1. | 0.471 |
| ACKR3 | CXCL10 | ENSOCUP00000009382 | ENSOCUP00000013990 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine. | 0.627 |
| ACKR3 | CXCL13 | ENSOCUP00000009382 | ENSOCUP00000019487 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine ligand 13. | 0.446 |
| ACKR3 | CXCL9 | ENSOCUP00000009382 | ENSOCUP00000026932 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine. | 0.623 |
| ACKR3 | CXCR4 | ENSOCUP00000009382 | ENSOCUP00000001655 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.990 |
| CCL2 | CCL21 | ENSOCUP00000015636 | ENSOCUP00000020728 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine ligand 21. | 0.701 |
| CCL2 | CCL5 | ENSOCUP00000015636 | ENSOCUP00000002470 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine. | 0.985 |
| CCL2 | CD4 | ENSOCUP00000015636 | ENSOCUP00000030708 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.900 |
| CCL2 | CD74 | ENSOCUP00000015636 | ENSOCUP00000003348 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | CD74 molecule. | 0.531 |
| CCL2 | CX3CL1 | ENSOCUP00000015636 | ENSOCUP00000006470 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X3-C motif chemokine ligand 1. | 0.890 |
| CCL2 | CXCL10 | ENSOCUP00000015636 | ENSOCUP00000013990 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine. | 0.942 |
| CCL2 | CXCL13 | ENSOCUP00000015636 | ENSOCUP00000019487 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine ligand 13. | 0.987 |
| CCL2 | CXCL9 | ENSOCUP00000015636 | ENSOCUP00000026932 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine. | 0.994 |
| CCL2 | CXCR4 | ENSOCUP00000015636 | ENSOCUP00000001655 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. | 0.995 |
| CCL21 | ACKR3 | ENSOCUP00000020728 | ENSOCUP00000009382 | C-C motif chemokine ligand 21. | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.609 |
| CCL21 | CCL2 | ENSOCUP00000020728 | ENSOCUP00000015636 | C-C motif chemokine ligand 21. | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | 0.701 |
| CCL21 | CCL5 | ENSOCUP00000020728 | ENSOCUP00000002470 | C-C motif chemokine ligand 21. | C-C motif chemokine. | 0.991 |
| CCL21 | CD4 | ENSOCUP00000020728 | ENSOCUP00000030708 | C-C motif chemokine ligand 21. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.813 |