DYRK4 protein (Oryctolagus cuniculus) - STRING interaction network

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DYRK4

Dual specificity tyrosine phosphorylation regulated kinase 4. (637 aa)

Predicted Functional Partners:

DYRK2

0.837

DCAF7

0.768

AAR2

0.592

ATM

0.579

TP53

0.549

G1U940_RABIT

0.549

RNF169

0.522

BPIFB6

0.517

CCNL2

0.516

DCAF1

0.502

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAR2	DYRK4	ENSOCUP00000004760	ENSOCUP00000001691	Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family.	Dual specificity tyrosine phosphorylation regulated kinase 4.	0.592
ATM	DYRK2	ENSOCUP00000012638	ENSOCUP00000025593	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.853
ATM	DYRK4	ENSOCUP00000012638	ENSOCUP00000001691	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 4.	0.579
ATM	G1U940_RABIT	ENSOCUP00000012638	ENSOCUP00000025959	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.963
ATM	RNF169	ENSOCUP00000012638	ENSOCUP00000001537	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ring finger protein 169.	0.649
ATM	TP53	ENSOCUP00000012638	ENSOCUP00000000989	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.990
BPIFB6	DYRK4	ENSOCUP00000005893	ENSOCUP00000001691	BPI fold containing family B member 6.	Dual specificity tyrosine phosphorylation regulated kinase 4.	0.517
CCNL2	DCAF7	ENSOCUP00000042595	ENSOCUP00000013632	Cyclin L2; Belongs to the cyclin family.	DDB1 and CUL4 associated factor 7.	0.401
CCNL2	DYRK2	ENSOCUP00000042595	ENSOCUP00000025593	Cyclin L2; Belongs to the cyclin family.	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.421
CCNL2	DYRK4	ENSOCUP00000042595	ENSOCUP00000001691	Cyclin L2; Belongs to the cyclin family.	Dual specificity tyrosine phosphorylation regulated kinase 4.	0.516
CCNL2	G1U940_RABIT	ENSOCUP00000042595	ENSOCUP00000025959	Cyclin L2; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.460
CCNL2	TP53	ENSOCUP00000042595	ENSOCUP00000000989	Cyclin L2; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.460
DCAF1	DYRK2	ENSOCUP00000008904	ENSOCUP00000025593	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.865
DCAF1	DYRK4	ENSOCUP00000008904	ENSOCUP00000001691	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 4.	0.502
DCAF1	G1U940_RABIT	ENSOCUP00000008904	ENSOCUP00000025959	DDB1 and CUL4 associated factor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.504
DCAF1	TP53	ENSOCUP00000008904	ENSOCUP00000000989	DDB1 and CUL4 associated factor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.504
DCAF7	CCNL2	ENSOCUP00000013632	ENSOCUP00000042595	DDB1 and CUL4 associated factor 7.	Cyclin L2; Belongs to the cyclin family.	0.401
DCAF7	DYRK2	ENSOCUP00000013632	ENSOCUP00000025593	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.691
DCAF7	DYRK4	ENSOCUP00000013632	ENSOCUP00000001691	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 4.	0.768
DCAF7	RNF169	ENSOCUP00000013632	ENSOCUP00000001537	DDB1 and CUL4 associated factor 7.	Ring finger protein 169.	0.916