UFL1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

UFL1

UFM1 specific ligase 1. (793 aa)

Predicted Functional Partners:

DDRGK1

0.987

CDK5RAP3

0.981

UBA5

0.972

UFC1

0.962

UFSP2

0.942

UFM1

0.934

UEVLD

0.676

UBL3

0.664

UBA3

0.659

ATG7

0.604

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG7	UBA3	ENSOCUP00000033142	ENSOCUP00000007065	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin like modifier activating enzyme 3.	0.819
ATG7	UBA5	ENSOCUP00000033142	ENSOCUP00000027836	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin like modifier activating enzyme 5.	0.814
ATG7	UBL3	ENSOCUP00000033142	ENSOCUP00000001685	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin-like protein.	0.642
ATG7	UFC1	ENSOCUP00000033142	ENSOCUP00000002064	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.455
ATG7	UFL1	ENSOCUP00000033142	ENSOCUP00000001801	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	UFM1 specific ligase 1.	0.604
ATG7	UFM1	ENSOCUP00000033142	ENSOCUP00000044677	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.492
CDK5RAP3	DDRGK1	ENSOCUP00000036124	ENSOCUP00000010861	CDK5 regulatory subunit associated protein 3.	DDRGK domain containing 1.	0.983
CDK5RAP3	UBA5	ENSOCUP00000036124	ENSOCUP00000027836	CDK5 regulatory subunit associated protein 3.	Ubiquitin like modifier activating enzyme 5.	0.755
CDK5RAP3	UFC1	ENSOCUP00000036124	ENSOCUP00000002064	CDK5 regulatory subunit associated protein 3.	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.777
CDK5RAP3	UFL1	ENSOCUP00000036124	ENSOCUP00000001801	CDK5 regulatory subunit associated protein 3.	UFM1 specific ligase 1.	0.981
CDK5RAP3	UFM1	ENSOCUP00000036124	ENSOCUP00000044677	CDK5 regulatory subunit associated protein 3.	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.651
CDK5RAP3	UFSP2	ENSOCUP00000036124	ENSOCUP00000010651	CDK5 regulatory subunit associated protein 3.	UFM1 specific peptidase 2.	0.795
DDRGK1	CDK5RAP3	ENSOCUP00000010861	ENSOCUP00000036124	DDRGK domain containing 1.	CDK5 regulatory subunit associated protein 3.	0.983
DDRGK1	UBA5	ENSOCUP00000010861	ENSOCUP00000027836	DDRGK domain containing 1.	Ubiquitin like modifier activating enzyme 5.	0.814
DDRGK1	UFC1	ENSOCUP00000010861	ENSOCUP00000002064	DDRGK domain containing 1.	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.925
DDRGK1	UFL1	ENSOCUP00000010861	ENSOCUP00000001801	DDRGK domain containing 1.	UFM1 specific ligase 1.	0.987
DDRGK1	UFM1	ENSOCUP00000010861	ENSOCUP00000044677	DDRGK domain containing 1.	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.	0.878
DDRGK1	UFSP2	ENSOCUP00000010861	ENSOCUP00000010651	DDRGK domain containing 1.	UFM1 specific peptidase 2.	0.865
UBA3	ATG7	ENSOCUP00000007065	ENSOCUP00000033142	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.819
UBA3	UBA5	ENSOCUP00000007065	ENSOCUP00000027836	Ubiquitin like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 5.	0.863