OSBP protein (Oryctolagus cuniculus) - STRING interaction network

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OSBP

Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] (809 aa)

Predicted Functional Partners:

VAPB

0.966

ENSOCUP00000049020

0.960

RAB31

0.909

PLEK2

0.842

PI4KB

0.787

OSBP2

0.775

PLEK

0.754

MOSPD2

0.747

ACBD3

0.727

PI4KA

0.722

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACBD3	OSBP	ENSOCUP00000012372	ENSOCUP00000001854	Acyl-CoA binding domain containing 3.	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	0.727
ACBD3	PI4KA	ENSOCUP00000012372	ENSOCUP00000007800	Acyl-CoA binding domain containing 3.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.424
ACBD3	PI4KB	ENSOCUP00000012372	ENSOCUP00000027052	Acyl-CoA binding domain containing 3.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.919
ENSOCUP00000049020	MOSPD2	ENSOCUP00000049020	ENSOCUP00000035862	MSP domain-containing protein.	Motile sperm domain containing 2.	0.461
ENSOCUP00000049020	OSBP	ENSOCUP00000049020	ENSOCUP00000001854	MSP domain-containing protein.	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	0.960
ENSOCUP00000049020	OSBP2	ENSOCUP00000049020	ENSOCUP00000015325	MSP domain-containing protein.	Oxysterol-binding protein; Belongs to the OSBP family.	0.868
ENSOCUP00000049020	PI4KA	ENSOCUP00000049020	ENSOCUP00000007800	MSP domain-containing protein.	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.604
ENSOCUP00000049020	VAPB	ENSOCUP00000049020	ENSOCUP00000014170	MSP domain-containing protein.	VAMP associated protein B and C.	0.997
MOSPD2	ENSOCUP00000049020	ENSOCUP00000035862	ENSOCUP00000049020	Motile sperm domain containing 2.	MSP domain-containing protein.	0.461
MOSPD2	OSBP	ENSOCUP00000035862	ENSOCUP00000001854	Motile sperm domain containing 2.	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	0.747
MOSPD2	OSBP2	ENSOCUP00000035862	ENSOCUP00000015325	Motile sperm domain containing 2.	Oxysterol-binding protein; Belongs to the OSBP family.	0.499
MOSPD2	RAB31	ENSOCUP00000035862	ENSOCUP00000047923	Motile sperm domain containing 2.	MSP domain-containing protein.	0.772
MOSPD2	VAPB	ENSOCUP00000035862	ENSOCUP00000014170	Motile sperm domain containing 2.	VAMP associated protein B and C.	0.622
OSBP	ACBD3	ENSOCUP00000001854	ENSOCUP00000012372	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	Acyl-CoA binding domain containing 3.	0.727
OSBP	ENSOCUP00000049020	ENSOCUP00000001854	ENSOCUP00000049020	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	MSP domain-containing protein.	0.960
OSBP	MOSPD2	ENSOCUP00000001854	ENSOCUP00000035862	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	Motile sperm domain containing 2.	0.747
OSBP	OSBP2	ENSOCUP00000001854	ENSOCUP00000015325	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	Oxysterol-binding protein; Belongs to the OSBP family.	0.775
OSBP	PI4KA	ENSOCUP00000001854	ENSOCUP00000007800	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.	0.722
OSBP	PI4KB	ENSOCUP00000001854	ENSOCUP00000027052	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.787
OSBP	PLEK	ENSOCUP00000001854	ENSOCUP00000037540	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...]	Pleckstrin.	0.754

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