| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSOCUP00000049020 | OSBP | ENSOCUP00000049020 | ENSOCUP00000001854 | MSP domain-containing protein. | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | 0.955 |
| ENSOCUP00000049020 | PI4KA | ENSOCUP00000049020 | ENSOCUP00000007800 | MSP domain-containing protein. | Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. | 0.500 |
| ENSOCUP00000049020 | STARD3 | ENSOCUP00000049020 | ENSOCUP00000029736 | MSP domain-containing protein. | StAR related lipid transfer domain containing 3. | 0.906 |
| ENSOCUP00000049020 | VAPB | ENSOCUP00000049020 | ENSOCUP00000014170 | MSP domain-containing protein. | VAMP associated protein B and C. | 0.773 |
| ESYT1 | OSBP | ENSOCUP00000014916 | ENSOCUP00000001854 | Extended synaptotagmin 1. | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | 0.709 |
| ESYT1 | RAB31 | ENSOCUP00000014916 | ENSOCUP00000047923 | Extended synaptotagmin 1. | MSP domain-containing protein. | 0.630 |
| ESYT1 | VAPB | ENSOCUP00000014916 | ENSOCUP00000014170 | Extended synaptotagmin 1. | VAMP associated protein B and C. | 0.604 |
| NPC1 | OSBP | ENSOCUP00000026876 | ENSOCUP00000001854 | SSD domain-containing protein. | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | 0.737 |
| NPC1 | RAB31 | ENSOCUP00000026876 | ENSOCUP00000047923 | SSD domain-containing protein. | MSP domain-containing protein. | 0.542 |
| NPC1 | STARD3 | ENSOCUP00000026876 | ENSOCUP00000029736 | SSD domain-containing protein. | StAR related lipid transfer domain containing 3. | 0.738 |
| OSBP | ENSOCUP00000049020 | ENSOCUP00000001854 | ENSOCUP00000049020 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | MSP domain-containing protein. | 0.955 |
| OSBP | ESYT1 | ENSOCUP00000001854 | ENSOCUP00000014916 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | Extended synaptotagmin 1. | 0.709 |
| OSBP | NPC1 | ENSOCUP00000001854 | ENSOCUP00000026876 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | SSD domain-containing protein. | 0.737 |
| OSBP | PI4KA | ENSOCUP00000001854 | ENSOCUP00000007800 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. | 0.703 |
| OSBP | PI4KB | ENSOCUP00000001854 | ENSOCUP00000027052 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.720 |
| OSBP | PLEK | ENSOCUP00000001854 | ENSOCUP00000037540 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | Pleckstrin. | 0.775 |
| OSBP | PLEK2 | ENSOCUP00000001854 | ENSOCUP00000043716 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | Pleckstrin 2. | 0.812 |
| OSBP | RAB31 | ENSOCUP00000001854 | ENSOCUP00000047923 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | MSP domain-containing protein. | 0.957 |
| OSBP | STARD3 | ENSOCUP00000001854 | ENSOCUP00000029736 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | StAR related lipid transfer domain containing 3. | 0.708 |
| OSBP | VAPB | ENSOCUP00000001854 | ENSOCUP00000014170 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (By similarity). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydr [...] | VAMP associated protein B and C. | 0.881 |