CASP2 protein (Oryctolagus cuniculus) - STRING interaction network

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CASP2

Caspase 2; Belongs to the peptidase C14A family. (451 aa)

Predicted Functional Partners:

BID

0.956

CASP3

0.923

APAF1

0.907

LOC100354468

0.835

LOC100341515

0.835

CYCS

0.835

LOC100353673

0.835

G1TUQ7_RABIT

0.835

LOC108178730

0.835

LOC100357840

0.835

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BID	ENSOCUP00000010200	ENSOCUP00000013982	Apoptotic peptidase activating factor 1.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.513
APAF1	CASP2	ENSOCUP00000010200	ENSOCUP00000001859	Apoptotic peptidase activating factor 1.	Caspase 2; Belongs to the peptidase C14A family.	0.907
APAF1	CASP3	ENSOCUP00000010200	ENSOCUP00000036614	Apoptotic peptidase activating factor 1.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.996
APAF1	CYCS	ENSOCUP00000010200	ENSOCUP00000019281	Apoptotic peptidase activating factor 1.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.980
APAF1	G1TUQ7_RABIT	ENSOCUP00000010200	ENSOCUP00000020783	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.978
APAF1	LOC100341515	ENSOCUP00000010200	ENSOCUP00000017626	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.980
APAF1	LOC100353673	ENSOCUP00000010200	ENSOCUP00000020297	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
APAF1	LOC100354468	ENSOCUP00000010200	ENSOCUP00000015773	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.980
APAF1	LOC100357840	ENSOCUP00000010200	ENSOCUP00000021980	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.980
APAF1	LOC108178730	ENSOCUP00000010200	ENSOCUP00000021195	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.980
BID	APAF1	ENSOCUP00000013982	ENSOCUP00000010200	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Apoptotic peptidase activating factor 1.	0.513
BID	CASP2	ENSOCUP00000013982	ENSOCUP00000001859	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Caspase 2; Belongs to the peptidase C14A family.	0.956
BID	CASP3	ENSOCUP00000013982	ENSOCUP00000036614	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.916
BID	CYCS	ENSOCUP00000013982	ENSOCUP00000019281	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.757
BID	G1TUQ7_RABIT	ENSOCUP00000013982	ENSOCUP00000020783	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.756
BID	LOC100341515	ENSOCUP00000013982	ENSOCUP00000017626	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.758
BID	LOC100353673	ENSOCUP00000013982	ENSOCUP00000020297	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.757
BID	LOC100354468	ENSOCUP00000013982	ENSOCUP00000015773	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.758
BID	LOC100357840	ENSOCUP00000013982	ENSOCUP00000021980	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.758
BID	LOC108178730	ENSOCUP00000013982	ENSOCUP00000021195	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.758