Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)    
Predicted Functional Partners:
CUL3
Cullin 3; Belongs to the cullin family.
   
 0.957
BTK
Tyrosine-protein kinase.
   
 
 0.878
RPP25L
Ribonuclease P/MRP subunit p25 like.
    
 
 0.839
ZNF516
Zinc finger protein 516.
    
 0.698
CUL1
Cullin 1; Belongs to the cullin family.
   
 0.670
BMX
Tyrosine-protein kinase.
   
 
 0.658
EIF4A1
Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
    
 
 0.656
U3KMP9_RABIT
Uncharacterized protein; Belongs to the DEAD box helicase family.
    
 
 0.656
ENSOCUP00000035909
Uncharacterized protein; Belongs to the DEAD box helicase family.
    
 
 0.656
ENSOCUP00000046701
Uncharacterized protein; Belongs to the DEAD box helicase family.
    
 
 0.656
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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