PML protein (Oryctolagus cuniculus) - STRING interaction network

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Score

PML

Promyelocytic leukemia. (860 aa)

Predicted Functional Partners:

RARA

0.995

DAXX

0.988

EIF4E

0.924

CREBBP

0.879

UBE2I

0.876

SPIB

0.872

TP53

0.871

G1U940_RABIT

0.871

RARB

0.867

RARG

0.867

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	DAXX	ENSOCUP00000003854	ENSOCUP00000009116	CREB binding protein.	Death domain associated protein.	0.844
CREBBP	G1U940_RABIT	ENSOCUP00000003854	ENSOCUP00000025959	CREB binding protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.947
CREBBP	PML	ENSOCUP00000003854	ENSOCUP00000001884	CREB binding protein.	Promyelocytic leukemia.	0.879
CREBBP	RARA	ENSOCUP00000003854	ENSOCUP00000016610	CREB binding protein.	Retinoic acid receptor alpha.	0.746
CREBBP	RARB	ENSOCUP00000003854	ENSOCUP00000000618	CREB binding protein.	Retinoic acid receptor beta.	0.446
CREBBP	RARG	ENSOCUP00000003854	ENSOCUP00000041981	CREB binding protein.	Uncharacterized protein.	0.441
CREBBP	SPIB	ENSOCUP00000003854	ENSOCUP00000017492	CREB binding protein.	ETS domain-containing protein.	0.614
CREBBP	TP53	ENSOCUP00000003854	ENSOCUP00000000989	CREB binding protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.978
CREBBP	UBE2I	ENSOCUP00000003854	ENSOCUP00000026696	CREB binding protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.704
DAXX	CREBBP	ENSOCUP00000009116	ENSOCUP00000003854	Death domain associated protein.	CREB binding protein.	0.844
DAXX	G1U940_RABIT	ENSOCUP00000009116	ENSOCUP00000025959	Death domain associated protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.947
DAXX	PML	ENSOCUP00000009116	ENSOCUP00000001884	Death domain associated protein.	Promyelocytic leukemia.	0.988
DAXX	RARA	ENSOCUP00000009116	ENSOCUP00000016610	Death domain associated protein.	Retinoic acid receptor alpha.	0.490
DAXX	TP53	ENSOCUP00000009116	ENSOCUP00000000989	Death domain associated protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.968
DAXX	UBE2I	ENSOCUP00000009116	ENSOCUP00000026696	Death domain associated protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.857
EIF4E	PML	ENSOCUP00000032078	ENSOCUP00000001884	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).	Promyelocytic leukemia.	0.924
EIF4E	TP53	ENSOCUP00000032078	ENSOCUP00000000989	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.477
G1U940_RABIT	CREBBP	ENSOCUP00000025959	ENSOCUP00000003854	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	CREB binding protein.	0.947
G1U940_RABIT	DAXX	ENSOCUP00000025959	ENSOCUP00000009116	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Death domain associated protein.	0.947
G1U940_RABIT	PML	ENSOCUP00000025959	ENSOCUP00000001884	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Promyelocytic leukemia.	0.871