G1SH01_RABIT protein (Oryctolagus cuniculus)

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Score

G1SH01_RABIT

FHA domain-containing protein. (162 aa)

Predicted Functional Partners:

TP53BP1

0.923

ATM

0.907

SLF1

0.896

SMC6

0.888

NBN

0.870

KDM6A

0.846

BLM

0.842

KDM6B

0.836

TOPBP1

0.834

PWWP2A

0.824

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BLM	ENSOCUP00000012638	ENSOCUP00000012010	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BLM RecQ like helicase.	0.973
ATM	G1SH01_RABIT	ENSOCUP00000012638	ENSOCUP00000001885	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FHA domain-containing protein.	0.907
ATM	NBN	ENSOCUP00000012638	ENSOCUP00000029655	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.999
ATM	SLF1	ENSOCUP00000012638	ENSOCUP00000003718	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC5-SMC6 complex localization factor 1.	0.840
ATM	SMC6	ENSOCUP00000012638	ENSOCUP00000014879	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.409
ATM	TOPBP1	ENSOCUP00000012638	ENSOCUP00000010983	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA topoisomerase II binding protein 1.	0.956
ATM	TP53BP1	ENSOCUP00000012638	ENSOCUP00000048342	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.983
BLM	ATM	ENSOCUP00000012010	ENSOCUP00000012638	BLM RecQ like helicase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.973
BLM	G1SH01_RABIT	ENSOCUP00000012010	ENSOCUP00000001885	BLM RecQ like helicase.	FHA domain-containing protein.	0.842
BLM	NBN	ENSOCUP00000012010	ENSOCUP00000029655	BLM RecQ like helicase.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.786
BLM	PWWP2A	ENSOCUP00000012010	ENSOCUP00000004962	BLM RecQ like helicase.	PWWP domain containing 2A.	0.793
BLM	SLF1	ENSOCUP00000012010	ENSOCUP00000003718	BLM RecQ like helicase.	SMC5-SMC6 complex localization factor 1.	0.824
BLM	SMC6	ENSOCUP00000012010	ENSOCUP00000014879	BLM RecQ like helicase.	Uncharacterized protein.	0.881
BLM	TOPBP1	ENSOCUP00000012010	ENSOCUP00000010983	BLM RecQ like helicase.	DNA topoisomerase II binding protein 1.	0.875
BLM	TP53BP1	ENSOCUP00000012010	ENSOCUP00000048342	BLM RecQ like helicase.	Tumor protein p53 binding protein 1.	0.929
G1SH01_RABIT	ATM	ENSOCUP00000001885	ENSOCUP00000012638	FHA domain-containing protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.907
G1SH01_RABIT	BLM	ENSOCUP00000001885	ENSOCUP00000012010	FHA domain-containing protein.	BLM RecQ like helicase.	0.842
G1SH01_RABIT	KDM6A	ENSOCUP00000001885	ENSOCUP00000034429	FHA domain-containing protein.	Lysine demethylase 6A.	0.846
G1SH01_RABIT	KDM6B	ENSOCUP00000001885	ENSOCUP00000037251	FHA domain-containing protein.	Lysine demethylase 6B.	0.836
G1SH01_RABIT	NBN	ENSOCUP00000001885	ENSOCUP00000029655	FHA domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.870