STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ITGB8Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). (772 aa)    
Predicted Functional Partners:
ITGAV
Integrin subunit alpha V; Belongs to the integrin alpha chain family.
   
 0.999
ITGA3
Integrin subunit alpha 3; Belongs to the integrin alpha chain family.
    
 0.973
ITGA4
Integrin subunit alpha 4; Belongs to the integrin alpha chain family.
    
 0.972
ITGA9
Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.
    
 0.971
ITGA1
Integrin subunit alpha 1; Belongs to the integrin alpha chain family.
   
 0.962
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
    
 0.961
ITGA6
Integrin subunit alpha 6; Belongs to the integrin alpha chain family.
    
 0.950
ITGA5
Integrin subunit alpha 5; Belongs to the integrin alpha chain family.
    
 0.946
ITGA2
Integrin subunit alpha 2; Belongs to the integrin alpha chain family.
   
 0.944
ITGB2
Integrin beta.
  
  
0.943
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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