MLH1 protein (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	BRIP1	ENSOCUP00000003366	ENSOCUP00000005779	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 interacting protein C-terminal helicase 1.	0.998
BRCA1	EXO1	ENSOCUP00000003366	ENSOCUP00000013891	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Exonuclease 1.	0.943
BRCA1	MLH1	ENSOCUP00000003366	ENSOCUP00000038778	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL homolog 1.	0.980
BRCA1	MLH3	ENSOCUP00000003366	ENSOCUP00000033630	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL homolog 3.	0.412
BRCA1	MSH2	ENSOCUP00000003366	ENSOCUP00000008254	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.944
BRCA1	MSH3	ENSOCUP00000003366	ENSOCUP00000014543	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutS homolog 3.	0.653
BRCA1	MSH6	ENSOCUP00000003366	ENSOCUP00000012569	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.936
BRCA1	PMS2	ENSOCUP00000003366	ENSOCUP00000044838	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	PMS1 homolog 2, mismatch repair system component.	0.716
BRIP1	BRCA1	ENSOCUP00000005779	ENSOCUP00000003366	BRCA1 interacting protein C-terminal helicase 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.998
BRIP1	EXO1	ENSOCUP00000005779	ENSOCUP00000013891	BRCA1 interacting protein C-terminal helicase 1.	Exonuclease 1.	0.879
BRIP1	FAN1	ENSOCUP00000005779	ENSOCUP00000003722	BRCA1 interacting protein C-terminal helicase 1.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.662
BRIP1	MLH1	ENSOCUP00000005779	ENSOCUP00000038778	BRCA1 interacting protein C-terminal helicase 1.	MutL homolog 1.	0.994
BRIP1	MSH2	ENSOCUP00000005779	ENSOCUP00000008254	BRCA1 interacting protein C-terminal helicase 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.659
BRIP1	MSH6	ENSOCUP00000005779	ENSOCUP00000012569	BRCA1 interacting protein C-terminal helicase 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.500
BRIP1	PMS1	ENSOCUP00000005779	ENSOCUP00000010770	BRCA1 interacting protein C-terminal helicase 1.	PMS1 homolog 1, mismatch repair system component.	0.860
BRIP1	PMS2	ENSOCUP00000005779	ENSOCUP00000044838	BRCA1 interacting protein C-terminal helicase 1.	PMS1 homolog 2, mismatch repair system component.	0.994
EXO1	BRCA1	ENSOCUP00000013891	ENSOCUP00000003366	Exonuclease 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.943
EXO1	BRIP1	ENSOCUP00000013891	ENSOCUP00000005779	Exonuclease 1.	BRCA1 interacting protein C-terminal helicase 1.	0.879
EXO1	FAN1	ENSOCUP00000013891	ENSOCUP00000003722	Exonuclease 1.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.463
EXO1	MLH1	ENSOCUP00000013891	ENSOCUP00000038778	Exonuclease 1.	MutL homolog 1.	0.990