STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (623 aa)    
Predicted Functional Partners:
MAP2K5
Mitogen-activated protein kinase kinase 5.
  
0.990
SMYD3
SET and MYND domain containing 3.
   
 
 0.954
PAK2
Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]
   
0.936
PAK1
Non-specific serine/threonine protein kinase.
    
0.934
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
   
0.923
MAP3K3
Mitogen-activated protein kinase kinase kinase 3.
  
 
0.917
HV1A_RABIT
Ig heavy chain V-A1 region BS-5.
    
   0.900
G1TRG5_RABIT
Ig-like domain-containing protein.
    
   0.900
CCM2
CCM2 scaffold protein.
    
 0.837
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.754
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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