STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (623 aa)    
Predicted Functional Partners:
MAP2K5
Mitogen-activated protein kinase kinase 5.
    
 0.978
MAP3K3
Mitogen-activated protein kinase kinase kinase 3.
   
  0.939
SMYD3
SET and MYND domain containing 3.
    
 
 0.936
MAP3K4
Mitogen-activated protein kinase kinase kinase 4.
   
0.912
PAK2
Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]
    
 0.895
PAK1
Non-specific serine/threonine protein kinase.
    
 0.895
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
    
 0.875
MAP2K4
Mitogen-activated protein kinase kinase 4.
    
0.866
MAP3K1
Mitogen-activated protein kinase kinase kinase 1.
   
 
 0.857
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.853
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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