STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SACAdenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family (1626 aa)    
Predicted Functional Partners:
PRKACB
Protein kinase, cAMP-dependent, catalytic, beta
   
 0.898
PDE4B
Phosphodiesterase 4B, cAMP-specific
   
 0.874
PDE4A
Phosphodiesterase 4A, cAMP-specific
   
 0.867
PDE4D
Phosphodiesterase 4D, cAMP-specific
   
 0.850
PDE7A
Phosphodiesterase 7A
   
 0.846
PDE2A
Phosphodiesterase 2A, cGMP-stimulated
   
 0.841
PDE11A
Phosphodiesterase 11A
   
 0.840
PDE10A
Phosphodiesterase 10A
   
 0.840
PDE5A
Phosphodiesterase 5A, cGMP-specific
   
 0.840
PDE7B
Phosphodiesterase 7B
   
 0.839
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, Oryctolagus cuniculus, domestic rabbit, rabbit, rabbits
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