node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY10 | GCH1 | ENSOCUP00000001957 | ENSOCUP00000002657 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | GTP_cyclohydroI domain-containing protein. | 0.800 |
ADCY10 | ITPA | ENSOCUP00000001957 | ENSOCUP00000003524 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.900 |
ADCY10 | LOC100348238 | ENSOCUP00000001957 | ENSOCUP00000006275 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Uncharacterized protein. | 0.907 |
ADCY10 | LOC100356016 | ENSOCUP00000001957 | ENSOCUP00000015846 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.697 |
ADCY10 | NME6 | ENSOCUP00000001957 | ENSOCUP00000000478 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Nucleoside diphosphate kinase. | 0.697 |
ADCY10 | NME7 | ENSOCUP00000001957 | ENSOCUP00000005943 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.697 |
ADCY10 | NUDT2 | ENSOCUP00000001957 | ENSOCUP00000005385 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Nudix hydrolase 2. | 0.901 |
ADCY10 | PDE1C | ENSOCUP00000001957 | ENSOCUP00000039321 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Phosphodiesterase. | 0.736 |
ADCY10 | PKLR | ENSOCUP00000001957 | ENSOCUP00000012868 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.904 |
ADCY10 | PRKACB | ENSOCUP00000001957 | ENSOCUP00000043583 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.953 |
GCH1 | ADCY10 | ENSOCUP00000002657 | ENSOCUP00000001957 | GTP_cyclohydroI domain-containing protein. | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.800 |
GCH1 | ITPA | ENSOCUP00000002657 | ENSOCUP00000003524 | GTP_cyclohydroI domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.916 |
GCH1 | LOC100348238 | ENSOCUP00000002657 | ENSOCUP00000006275 | GTP_cyclohydroI domain-containing protein. | Uncharacterized protein. | 0.800 |
GCH1 | LOC100356016 | ENSOCUP00000002657 | ENSOCUP00000015846 | GTP_cyclohydroI domain-containing protein. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.823 |
GCH1 | NME6 | ENSOCUP00000002657 | ENSOCUP00000000478 | GTP_cyclohydroI domain-containing protein. | Nucleoside diphosphate kinase. | 0.823 |
GCH1 | NME7 | ENSOCUP00000002657 | ENSOCUP00000005943 | GTP_cyclohydroI domain-containing protein. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.823 |
GCH1 | NUDT2 | ENSOCUP00000002657 | ENSOCUP00000005385 | GTP_cyclohydroI domain-containing protein. | Nudix hydrolase 2. | 0.864 |
GCH1 | PKLR | ENSOCUP00000002657 | ENSOCUP00000012868 | GTP_cyclohydroI domain-containing protein. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.832 |
ITPA | ADCY10 | ENSOCUP00000003524 | ENSOCUP00000001957 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.900 |
ITPA | GCH1 | ENSOCUP00000003524 | ENSOCUP00000002657 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | GTP_cyclohydroI domain-containing protein. | 0.916 |