Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
VKORC1Vitamin K epoxide reductase complex subunit 1. (162 aa)    
Predicted Functional Partners:
GGCX
Gamma-glutamyl carboxylase.
   
 
 0.976
NQO1
NAD(P)H quinone dehydrogenase 1.
     
 0.920
NQO2
N-ribosyldihydronicotinamide:quinone reductase 2.
     
 0.810
TMX4
Thioredoxin related transmembrane protein 4.
   
  
 0.753
TRPT1
tRNA phosphotransferase 1.
   
  
 0.719
ENSOCUP00000040428
Uncharacterized protein.
     
  0.689
TTC9B
Tetratricopeptide repeat domain 9B.
      
 0.649
LOC100356754
Sulfatase domain-containing protein.
      
 0.642
TPMT
Thiopurine S-methyltransferase.
      
 0.637
MED8-2
Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
   
  
 0.585
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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