node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | ADRB3 | ENSOCUP00000020897 | ENSOCUP00000022221 | C1q domain-containing protein. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.585 |
ADIPOQ | CIDEA | ENSOCUP00000020897 | ENSOCUP00000009793 | C1q domain-containing protein. | Cell death inducing DFFA like effector a. | 0.779 |
ADIPOQ | ELOVL3 | ENSOCUP00000020897 | ENSOCUP00000013810 | C1q domain-containing protein. | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] | 0.545 |
ADIPOQ | INS | ENSOCUP00000020897 | ENSOCUP00000020463 | C1q domain-containing protein. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.939 |
ADIPOQ | LEP | ENSOCUP00000020897 | ENSOCUP00000008782 | C1q domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.988 |
ADIPOQ | LIPE | ENSOCUP00000020897 | ENSOCUP00000000016 | C1q domain-containing protein. | Lipase E, hormone sensitive type. | 0.825 |
ADIPOQ | PPARG | ENSOCUP00000020897 | ENSOCUP00000043929 | C1q domain-containing protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.930 |
ADIPOQ | PPARGC1A | ENSOCUP00000020897 | ENSOCUP00000034883 | C1q domain-containing protein. | PPARG coactivator 1 alpha. | 0.730 |
ADIPOQ | TMEM26 | ENSOCUP00000020897 | ENSOCUP00000019953 | C1q domain-containing protein. | Transmembrane protein 26. | 0.542 |
ADIPOQ | UCP1 | ENSOCUP00000020897 | ENSOCUP00000001977 | C1q domain-containing protein. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.876 |
ADRB3 | ADIPOQ | ENSOCUP00000022221 | ENSOCUP00000020897 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | C1q domain-containing protein. | 0.585 |
ADRB3 | CIDEA | ENSOCUP00000022221 | ENSOCUP00000009793 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Cell death inducing DFFA like effector a. | 0.693 |
ADRB3 | ELOVL3 | ENSOCUP00000022221 | ENSOCUP00000013810 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] | 0.432 |
ADRB3 | INS | ENSOCUP00000022221 | ENSOCUP00000020463 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.470 |
ADRB3 | LEP | ENSOCUP00000022221 | ENSOCUP00000008782 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.565 |
ADRB3 | LIPE | ENSOCUP00000022221 | ENSOCUP00000000016 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Lipase E, hormone sensitive type. | 0.737 |
ADRB3 | PPARG | ENSOCUP00000022221 | ENSOCUP00000043929 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.574 |
ADRB3 | PPARGC1A | ENSOCUP00000022221 | ENSOCUP00000034883 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | PPARG coactivator 1 alpha. | 0.600 |
ADRB3 | TMEM26 | ENSOCUP00000022221 | ENSOCUP00000019953 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Transmembrane protein 26. | 0.433 |
ADRB3 | UCP1 | ENSOCUP00000022221 | ENSOCUP00000001977 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.860 |