Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (342 aa)    
Predicted Functional Partners:
ST14
Suppression of tumorigenicity 14.
  
 
0.903
SPINT2
Serine peptidase inhibitor, Kunitz type 2.
    
 0.681
SPINT1
Serine peptidase inhibitor, Kunitz type 1.
   
 0.665
AQP6
Aquaporin 6; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
 
 0.647
TMPRSS4
Transmembrane serine protease 4; Belongs to the peptidase S1 family.
  
0.610
SEC14L5
SEC14 like lipid binding 5.
   
 
 0.597
CLDN7
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.591
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
   
 
 0.591
SCNN1B
Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...]
   
  
 0.580
UMOD
Uromodulin.
   
 0.578
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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