MAT2A protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMD1	DNMT3A	ENSOCUP00000004926	ENSOCUP00000024004	Uncharacterized protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.755
AMD1	GNMT	ENSOCUP00000004926	ENSOCUP00000003341	Uncharacterized protein.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	0.888
AMD1	MAT2A	ENSOCUP00000004926	ENSOCUP00000002040	Uncharacterized protein.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.885
AMD1	MAT2B	ENSOCUP00000004926	ENSOCUP00000029684	Uncharacterized protein.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.823
AMD1	MTHFR	ENSOCUP00000004926	ENSOCUP00000006304	Uncharacterized protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.535
AMD1	MTR	ENSOCUP00000004926	ENSOCUP00000008420	Uncharacterized protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.456
AMD1	SMS	ENSOCUP00000004926	ENSOCUP00000042203	Uncharacterized protein.	Spermine synthase.	0.946
AMD1	TAT	ENSOCUP00000004926	ENSOCUP00000008578	Uncharacterized protein.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.457
BHMT	CTH	ENSOCUP00000031900	ENSOCUP00000006510	Hcy-binding domain-containing protein.	Cystathionine gamma-lyase.	0.964
BHMT	GNMT	ENSOCUP00000031900	ENSOCUP00000003341	Hcy-binding domain-containing protein.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	0.786
BHMT	MAT2A	ENSOCUP00000031900	ENSOCUP00000002040	Hcy-binding domain-containing protein.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.970
BHMT	MAT2B	ENSOCUP00000031900	ENSOCUP00000029684	Hcy-binding domain-containing protein.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.949
BHMT	MTHFR	ENSOCUP00000031900	ENSOCUP00000006304	Hcy-binding domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.961
BHMT	MTR	ENSOCUP00000031900	ENSOCUP00000008420	Hcy-binding domain-containing protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.971
BHMT	TAT	ENSOCUP00000031900	ENSOCUP00000008578	Hcy-binding domain-containing protein.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.910
CTH	BHMT	ENSOCUP00000006510	ENSOCUP00000031900	Cystathionine gamma-lyase.	Hcy-binding domain-containing protein.	0.964
CTH	GNMT	ENSOCUP00000006510	ENSOCUP00000003341	Cystathionine gamma-lyase.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	0.617
CTH	MAT2A	ENSOCUP00000006510	ENSOCUP00000002040	Cystathionine gamma-lyase.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.895
CTH	MTHFR	ENSOCUP00000006510	ENSOCUP00000006304	Cystathionine gamma-lyase.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.965
CTH	MTR	ENSOCUP00000006510	ENSOCUP00000008420	Cystathionine gamma-lyase.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.969