Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (478 aa)    
Predicted Functional Partners:
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.986
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.941
IRAK4
Interleukin 1 receptor associated kinase 4.
    
 0.913
IRAK2
Interleukin 1 receptor associated kinase 2.
    
 0.709
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.697
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.685
PGBD2
PiggyBac transposable element derived 2.
      
 0.673
NEK9
NIMA related kinase 9.
    
 
 0.647
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    
 0.638
MYD88
Uncharacterized protein.
    
 
 0.598
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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