| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCY3 | ADCY4 | ENSOCUP00000013273 | ENSOCUP00000002576 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.446 |
| ADCY3 | ADCY6 | ENSOCUP00000013273 | ENSOCUP00000040719 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.945 |
| ADCY3 | ADCY8 | ENSOCUP00000013273 | ENSOCUP00000002325 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.947 |
| ADCY3 | CALM1 | ENSOCUP00000013273 | ENSOCUP00000010025 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | 0.934 |
| ADCY3 | CALML5 | ENSOCUP00000013273 | ENSOCUP00000010863 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Calmodulin like 5. | 0.932 |
| ADCY3 | GNAS | ENSOCUP00000013273 | ENSOCUP00000049763 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GNAS complex locus. | 0.959 |
| ADCY3 | PRKACB | ENSOCUP00000013273 | ENSOCUP00000043583 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.940 |
| ADCY3 | PRKCB | ENSOCUP00000013273 | ENSOCUP00000046202 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.903 |
| ADCY3 | RAPGEF3 | ENSOCUP00000013273 | ENSOCUP00000024355 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Ras-GEF domain-containing protein. | 0.909 |
| ADCY3 | RAPGEF4 | ENSOCUP00000013273 | ENSOCUP00000012925 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Rap guanine nucleotide exchange factor 4. | 0.928 |
| ADCY4 | ADCY3 | ENSOCUP00000002576 | ENSOCUP00000013273 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.446 |
| ADCY4 | ADCY6 | ENSOCUP00000002576 | ENSOCUP00000040719 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.971 |
| ADCY4 | ADCY8 | ENSOCUP00000002576 | ENSOCUP00000002325 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.954 |
| ADCY4 | CALM1 | ENSOCUP00000002576 | ENSOCUP00000010025 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | 0.923 |
| ADCY4 | CALML5 | ENSOCUP00000002576 | ENSOCUP00000010863 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Calmodulin like 5. | 0.923 |
| ADCY4 | GNAS | ENSOCUP00000002576 | ENSOCUP00000049763 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GNAS complex locus. | 0.963 |
| ADCY4 | PRKACB | ENSOCUP00000002576 | ENSOCUP00000043583 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.945 |
| ADCY4 | PRKCB | ENSOCUP00000002576 | ENSOCUP00000046202 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.904 |
| ADCY4 | RAPGEF3 | ENSOCUP00000002576 | ENSOCUP00000024355 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Ras-GEF domain-containing protein. | 0.929 |
| ADCY4 | RAPGEF4 | ENSOCUP00000002576 | ENSOCUP00000012925 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Rap guanine nucleotide exchange factor 4. | 0.936 |