IGFBP4 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IGFBP4

Insulin like growth factor binding protein 4. (258 aa)

Predicted Functional Partners:

IGF1

0.983

IGFBP1

0.866

PAPPA

0.719

LRP6

0.599

CCL28

0.569

IGFBP6

0.562

IGFBP2

0.543

IGFBP5

0.516

PAPPA2

0.511

VIPR1

0.485

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL28	IGFBP4	ENSOCUP00000008831	ENSOCUP00000002450	SCY domain-containing protein.	Insulin like growth factor binding protein 4.	0.569
IGF1	IGFBP1	ENSOCUP00000021389	ENSOCUP00000011037	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 1.	0.998
IGF1	IGFBP2	ENSOCUP00000021389	ENSOCUP00000034628	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	IGFBP N-terminal domain-containing protein.	0.998
IGF1	IGFBP4	ENSOCUP00000021389	ENSOCUP00000002450	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 4.	0.983
IGF1	IGFBP5	ENSOCUP00000021389	ENSOCUP00000023885	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 5.	0.997
IGF1	IGFBP6	ENSOCUP00000021389	ENSOCUP00000001216	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 6.	0.990
IGF1	PAPPA	ENSOCUP00000021389	ENSOCUP00000001261	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Pappalysin 1.	0.723
IGF1	PAPPA2	ENSOCUP00000021389	ENSOCUP00000013349	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Pappalysin 2.	0.548
IGFBP1	IGF1	ENSOCUP00000011037	ENSOCUP00000021389	Insulin like growth factor binding protein 1.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.998
IGFBP1	IGFBP2	ENSOCUP00000011037	ENSOCUP00000034628	Insulin like growth factor binding protein 1.	IGFBP N-terminal domain-containing protein.	0.586
IGFBP1	IGFBP4	ENSOCUP00000011037	ENSOCUP00000002450	Insulin like growth factor binding protein 1.	Insulin like growth factor binding protein 4.	0.866
IGFBP1	IGFBP5	ENSOCUP00000011037	ENSOCUP00000023885	Insulin like growth factor binding protein 1.	Insulin like growth factor binding protein 5.	0.479
IGFBP1	IGFBP6	ENSOCUP00000011037	ENSOCUP00000001216	Insulin like growth factor binding protein 1.	Insulin like growth factor binding protein 6.	0.832
IGFBP2	IGF1	ENSOCUP00000034628	ENSOCUP00000021389	IGFBP N-terminal domain-containing protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.998
IGFBP2	IGFBP1	ENSOCUP00000034628	ENSOCUP00000011037	IGFBP N-terminal domain-containing protein.	Insulin like growth factor binding protein 1.	0.586
IGFBP2	IGFBP4	ENSOCUP00000034628	ENSOCUP00000002450	IGFBP N-terminal domain-containing protein.	Insulin like growth factor binding protein 4.	0.543
IGFBP2	IGFBP5	ENSOCUP00000034628	ENSOCUP00000023885	IGFBP N-terminal domain-containing protein.	Insulin like growth factor binding protein 5.	0.430
IGFBP2	IGFBP6	ENSOCUP00000034628	ENSOCUP00000001216	IGFBP N-terminal domain-containing protein.	Insulin like growth factor binding protein 6.	0.551
IGFBP2	PAPPA	ENSOCUP00000034628	ENSOCUP00000001261	IGFBP N-terminal domain-containing protein.	Pappalysin 1.	0.540
IGFBP4	CCL28	ENSOCUP00000002450	ENSOCUP00000008831	Insulin like growth factor binding protein 4.	SCY domain-containing protein.	0.569