SLK protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SLK

STE20 like kinase. (1241 aa)

Predicted Functional Partners:

PLK1

0.864

CDK1

0.851

CCNB2

0.755

CCNB1

0.755

KEAP1

0.668

YWHAB

0.661

EZR

0.613

LOC100351807

0.610

LOC100341292

0.610

ENSOCUP00000042835

0.610

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNB1	CCNB2	ENSOCUP00000003748	ENSOCUP00000001415	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin B2; Belongs to the cyclin family.	0.449
CCNB1	CDK1	ENSOCUP00000003748	ENSOCUP00000002479	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.999
CCNB1	PLK1	ENSOCUP00000003748	ENSOCUP00000007325	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Serine/threonine-protein kinase PLK.	0.996
CCNB1	SLK	ENSOCUP00000003748	ENSOCUP00000002644	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	STE20 like kinase.	0.755
CCNB1	YWHAB	ENSOCUP00000003748	ENSOCUP00000034985	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.499
CCNB2	CCNB1	ENSOCUP00000001415	ENSOCUP00000003748	Cyclin B2; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.449
CCNB2	CDK1	ENSOCUP00000001415	ENSOCUP00000002479	Cyclin B2; Belongs to the cyclin family.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.999
CCNB2	PLK1	ENSOCUP00000001415	ENSOCUP00000007325	Cyclin B2; Belongs to the cyclin family.	Serine/threonine-protein kinase PLK.	0.996
CCNB2	SLK	ENSOCUP00000001415	ENSOCUP00000002644	Cyclin B2; Belongs to the cyclin family.	STE20 like kinase.	0.755
CCNB2	YWHAB	ENSOCUP00000001415	ENSOCUP00000034985	Cyclin B2; Belongs to the cyclin family.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.	0.499
CDK1	CCNB1	ENSOCUP00000002479	ENSOCUP00000003748	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.999
CDK1	CCNB2	ENSOCUP00000002479	ENSOCUP00000001415	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin B2; Belongs to the cyclin family.	0.999
CDK1	PLK1	ENSOCUP00000002479	ENSOCUP00000007325	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.995
CDK1	SLK	ENSOCUP00000002479	ENSOCUP00000002644	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	STE20 like kinase.	0.851
ENSOCUP00000042835	LOC100351807	ENSOCUP00000042835	ENSOCUP00000008528	annotation not available	Uncharacterized protein.	0.801
ENSOCUP00000042835	SLK	ENSOCUP00000042835	ENSOCUP00000002644	annotation not available	STE20 like kinase.	0.610
EZR	SLK	ENSOCUP00000040029	ENSOCUP00000002644	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	STE20 like kinase.	0.613
KEAP1	SLK	ENSOCUP00000044015	ENSOCUP00000002644	Kelch like ECH associated protein 1.	STE20 like kinase.	0.668
LOC100341292	SLK	ENSOCUP00000036133	ENSOCUP00000002644	Uncharacterized protein.	STE20 like kinase.	0.610
LOC100351807	ENSOCUP00000042835	ENSOCUP00000008528	ENSOCUP00000042835	Uncharacterized protein.	annotation not available	0.801