Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCR7 | CD1A | ENSOCUP00000017477 | ENSOCUP00000036769 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Ig-like domain-containing protein. | 0.625 |
| CCR7 | CD1C | ENSOCUP00000017477 | ENSOCUP00000047542 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Ig-like domain-containing protein. | 0.679 |
| CCR7 | CD4 | ENSOCUP00000017477 | ENSOCUP00000030708 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.907 |
| CCR7 | CD40 | ENSOCUP00000017477 | ENSOCUP00000034264 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.822 |
| CCR7 | CD80 | ENSOCUP00000017477 | ENSOCUP00000008197 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. | 0.854 |
| CCR7 | CD83 | ENSOCUP00000017477 | ENSOCUP00000002867 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | CD83 molecule. | 0.818 |
| CCR7 | CD86 | ENSOCUP00000017477 | ENSOCUP00000035010 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. | 0.872 |
| CCR7 | CSF2 | ENSOCUP00000017477 | ENSOCUP00000002976 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Uncharacterized protein. | 0.708 |
| CCR7 | IL10 | ENSOCUP00000017477 | ENSOCUP00000019534 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.787 |
| CCR7 | IL4 | ENSOCUP00000017477 | ENSOCUP00000025135 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.766 |
| CD1A | CCR7 | ENSOCUP00000036769 | ENSOCUP00000017477 | Ig-like domain-containing protein. | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.625 |
| CD1A | CD1C | ENSOCUP00000036769 | ENSOCUP00000047542 | Ig-like domain-containing protein. | Ig-like domain-containing protein. | 0.500 |
| CD1A | CD4 | ENSOCUP00000036769 | ENSOCUP00000030708 | Ig-like domain-containing protein. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.776 |
| CD1A | CD40 | ENSOCUP00000036769 | ENSOCUP00000034264 | Ig-like domain-containing protein. | Uncharacterized protein. | 0.770 |
| CD1A | CD80 | ENSOCUP00000036769 | ENSOCUP00000008197 | Ig-like domain-containing protein. | T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. | 0.849 |
| CD1A | CD83 | ENSOCUP00000036769 | ENSOCUP00000002867 | Ig-like domain-containing protein. | CD83 molecule. | 0.872 |
| CD1A | CD86 | ENSOCUP00000036769 | ENSOCUP00000035010 | Ig-like domain-containing protein. | T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. | 0.854 |
| CD1A | CSF2 | ENSOCUP00000036769 | ENSOCUP00000002976 | Ig-like domain-containing protein. | Uncharacterized protein. | 0.779 |
| CD1A | IL10 | ENSOCUP00000036769 | ENSOCUP00000019534 | Ig-like domain-containing protein. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.665 |
| CD1A | IL4 | ENSOCUP00000036769 | ENSOCUP00000025135 | Ig-like domain-containing protein. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.776 |
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