SLFN11 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

SLFN11

Schlafen family member 13. (904 aa)

Predicted Functional Partners:

VCL

0.647

SAMHD1

0.572

EVA1B

0.560

REL

0.552

TOP1

0.543

CMPK2

0.537

SLFNL1

0.504

AFAP1L1

0.493

MGP

0.490

BRCA1

0.461

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFAP1L1	SLFN11	ENSOCUP00000013853	ENSOCUP00000003040	Actin filament associated protein 1 like 1.	Schlafen family member 13.	0.493
BRCA1	REL	ENSOCUP00000003366	ENSOCUP00000004298	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	REL proto-oncogene, NF-kB subunit.	0.566
BRCA1	SLFN11	ENSOCUP00000003366	ENSOCUP00000003040	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Schlafen family member 13.	0.461
BRCA1	TOP1	ENSOCUP00000003366	ENSOCUP00000007107	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.737
BRCA1	VCL	ENSOCUP00000003366	ENSOCUP00000039299	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Vinculin.	0.516
CMPK2	EVA1B	ENSOCUP00000008630	ENSOCUP00000017290	Cytidine/uridine monophosphate kinase 2.	FAM176 domain-containing protein.	0.539
CMPK2	SLFN11	ENSOCUP00000008630	ENSOCUP00000003040	Cytidine/uridine monophosphate kinase 2.	Schlafen family member 13.	0.537
EVA1B	CMPK2	ENSOCUP00000017290	ENSOCUP00000008630	FAM176 domain-containing protein.	Cytidine/uridine monophosphate kinase 2.	0.539
EVA1B	SLFN11	ENSOCUP00000017290	ENSOCUP00000003040	FAM176 domain-containing protein.	Schlafen family member 13.	0.560
MGP	SLFN11	ENSOCUP00000014573	ENSOCUP00000003040	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.	Schlafen family member 13.	0.490
MGP	VCL	ENSOCUP00000014573	ENSOCUP00000039299	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.	Vinculin.	0.560
REL	BRCA1	ENSOCUP00000004298	ENSOCUP00000003366	REL proto-oncogene, NF-kB subunit.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.566
REL	SLFN11	ENSOCUP00000004298	ENSOCUP00000003040	REL proto-oncogene, NF-kB subunit.	Schlafen family member 13.	0.552
SAMHD1	SLFN11	ENSOCUP00000006581	ENSOCUP00000003040	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	Schlafen family member 13.	0.572
SLFN11	AFAP1L1	ENSOCUP00000003040	ENSOCUP00000013853	Schlafen family member 13.	Actin filament associated protein 1 like 1.	0.493
SLFN11	BRCA1	ENSOCUP00000003040	ENSOCUP00000003366	Schlafen family member 13.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.461
SLFN11	CMPK2	ENSOCUP00000003040	ENSOCUP00000008630	Schlafen family member 13.	Cytidine/uridine monophosphate kinase 2.	0.537
SLFN11	EVA1B	ENSOCUP00000003040	ENSOCUP00000017290	Schlafen family member 13.	FAM176 domain-containing protein.	0.560
SLFN11	MGP	ENSOCUP00000003040	ENSOCUP00000014573	Schlafen family member 13.	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.	0.490
SLFN11	REL	ENSOCUP00000003040	ENSOCUP00000004298	Schlafen family member 13.	REL proto-oncogene, NF-kB subunit.	0.552