FMO3 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

FMO3

Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] (531 aa)

Predicted Functional Partners:

CYP3A6

0.793

GADL1

0.774

GGT7

0.774

GAD2

0.774

CSAD

0.774

GGT6

0.774

GGT5

0.767

G1TLQ2_RABIT

0.763

ADO

0.755

LOC100350872

0.685

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADO	CSAD	ENSOCUP00000016218	ENSOCUP00000017312	2-aminoethanethiol dioxygenase.	Cysteine sulfinic acid decarboxylase.	0.949
ADO	FMO3	ENSOCUP00000016218	ENSOCUP00000003129	2-aminoethanethiol dioxygenase.	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	0.755
ADO	GAD2	ENSOCUP00000016218	ENSOCUP00000015017	2-aminoethanethiol dioxygenase.	Glutamate decarboxylase 2.	0.851
ADO	GADL1	ENSOCUP00000016218	ENSOCUP00000000682	2-aminoethanethiol dioxygenase.	Glutamate decarboxylase like 1.	0.888
CSAD	ADO	ENSOCUP00000017312	ENSOCUP00000016218	Cysteine sulfinic acid decarboxylase.	2-aminoethanethiol dioxygenase.	0.949
CSAD	FMO3	ENSOCUP00000017312	ENSOCUP00000003129	Cysteine sulfinic acid decarboxylase.	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	0.774
CSAD	G1TLQ2_RABIT	ENSOCUP00000017312	ENSOCUP00000017904	Cysteine sulfinic acid decarboxylase.	Uncharacterized protein.	0.861
CSAD	GAD2	ENSOCUP00000017312	ENSOCUP00000015017	Cysteine sulfinic acid decarboxylase.	Glutamate decarboxylase 2.	0.822
CSAD	GADL1	ENSOCUP00000017312	ENSOCUP00000000682	Cysteine sulfinic acid decarboxylase.	Glutamate decarboxylase like 1.	0.851
CSAD	GGT5	ENSOCUP00000017312	ENSOCUP00000043016	Cysteine sulfinic acid decarboxylase.	Gamma-glutamyltransferase 5.	0.871
CSAD	GGT6	ENSOCUP00000017312	ENSOCUP00000049326	Cysteine sulfinic acid decarboxylase.	Gamma-glutamyltransferase 6.	0.861
CSAD	GGT7	ENSOCUP00000017312	ENSOCUP00000001945	Cysteine sulfinic acid decarboxylase.	Gamma-glutamyltransferase 7.	0.863
CSAD	LOC100350872	ENSOCUP00000017312	ENSOCUP00000015965	Cysteine sulfinic acid decarboxylase.	Uncharacterized protein.	0.906
CYP3A6	FMO3	ENSOCUP00000034396	ENSOCUP00000003129	Cytochrome P450 3A6; Exhibits progesterone 6 beta-hydroxylase activity.	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	0.793
FMO3	ADO	ENSOCUP00000003129	ENSOCUP00000016218	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	2-aminoethanethiol dioxygenase.	0.755
FMO3	CSAD	ENSOCUP00000003129	ENSOCUP00000017312	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	Cysteine sulfinic acid decarboxylase.	0.774
FMO3	CYP3A6	ENSOCUP00000003129	ENSOCUP00000034396	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	Cytochrome P450 3A6; Exhibits progesterone 6 beta-hydroxylase activity.	0.793
FMO3	G1TLQ2_RABIT	ENSOCUP00000003129	ENSOCUP00000017904	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	Uncharacterized protein.	0.763
FMO3	GAD2	ENSOCUP00000003129	ENSOCUP00000015017	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	Glutamate decarboxylase 2.	0.774
FMO3	GADL1	ENSOCUP00000003129	ENSOCUP00000000682	Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...]	Glutamate decarboxylase like 1.	0.774

page 1 of 5

Server load: low (36%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About