node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHMT | CBS | ENSOCUP00000031900 | ENSOCUP00000034549 | Hcy-binding domain-containing protein. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.982 |
BHMT | MMADHC | ENSOCUP00000031900 | ENSOCUP00000027129 | Hcy-binding domain-containing protein. | Metabolism of cobalamin associated D. | 0.683 |
BHMT | MTHFR | ENSOCUP00000031900 | ENSOCUP00000006304 | Hcy-binding domain-containing protein. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.987 |
BHMT | MTR | ENSOCUP00000031900 | ENSOCUP00000008420 | Hcy-binding domain-containing protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.976 |
BHMT | MTRR | ENSOCUP00000031900 | ENSOCUP00000003139 | Hcy-binding domain-containing protein. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.829 |
CBS | BHMT | ENSOCUP00000034549 | ENSOCUP00000031900 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Hcy-binding domain-containing protein. | 0.982 |
CBS | FLAD1 | ENSOCUP00000034549 | ENSOCUP00000021373 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.832 |
CBS | MTHFR | ENSOCUP00000034549 | ENSOCUP00000006304 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.913 |
CBS | MTR | ENSOCUP00000034549 | ENSOCUP00000008420 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.986 |
CBS | MTRR | ENSOCUP00000034549 | ENSOCUP00000003139 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.916 |
CIAPIN1 | MTRR | ENSOCUP00000035898 | ENSOCUP00000003139 | Cytokine induced apoptosis inhibitor 1. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.808 |
CYP4X1 | MTRR | ENSOCUP00000007151 | ENSOCUP00000003139 | Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.912 |
FASTKD3 | MTRR | ENSOCUP00000041735 | ENSOCUP00000003139 | FAST kinase domains 3. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.777 |
FLAD1 | CBS | ENSOCUP00000021373 | ENSOCUP00000034549 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.832 |
FLAD1 | MTHFR | ENSOCUP00000021373 | ENSOCUP00000006304 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.734 |
FLAD1 | MTRR | ENSOCUP00000021373 | ENSOCUP00000003139 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.866 |
MMACHC | MMADHC | ENSOCUP00000005152 | ENSOCUP00000027129 | Metabolism of cobalamin associated C. | Metabolism of cobalamin associated D. | 0.959 |
MMACHC | MTR | ENSOCUP00000005152 | ENSOCUP00000008420 | Metabolism of cobalamin associated C. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.856 |
MMACHC | MTRR | ENSOCUP00000005152 | ENSOCUP00000003139 | Metabolism of cobalamin associated C. | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. | 0.884 |
MMADHC | BHMT | ENSOCUP00000027129 | ENSOCUP00000031900 | Metabolism of cobalamin associated D. | Hcy-binding domain-containing protein. | 0.683 |