SLC6A4 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SLC6A4

Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (777 aa)

Predicted Functional Partners:

TPH2

0.804

HTR2C

0.767

HTR2A

0.759

SLC18A2

0.744

HTR1A

0.742

DRD2

0.725

HTR1D

0.720

MAOA

0.706

COMT

0.699

HTR2B

0.684

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COMT	DRD2	ENSOCUP00000048218	ENSOCUP00000010023	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.788
COMT	HTR2A	ENSOCUP00000048218	ENSOCUP00000008591	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	5-hydroxytryptamine receptor 2A.	0.509
COMT	MAOA	ENSOCUP00000048218	ENSOCUP00000001233	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Amine oxidase.	0.875
COMT	SLC18A2	ENSOCUP00000048218	ENSOCUP00000010393	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Solute carrier family 18 member A2.	0.410
COMT	SLC6A4	ENSOCUP00000048218	ENSOCUP00000003158	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.699
COMT	TPH2	ENSOCUP00000048218	ENSOCUP00000049818	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Tryptophan hydroxylase 2.	0.410
DRD2	COMT	ENSOCUP00000010023	ENSOCUP00000048218	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.788
DRD2	HTR2A	ENSOCUP00000010023	ENSOCUP00000008591	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	5-hydroxytryptamine receptor 2A.	0.508
DRD2	MAOA	ENSOCUP00000010023	ENSOCUP00000001233	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Amine oxidase.	0.536
DRD2	SLC18A2	ENSOCUP00000010023	ENSOCUP00000010393	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Solute carrier family 18 member A2.	0.612
DRD2	SLC6A4	ENSOCUP00000010023	ENSOCUP00000003158	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.725
HTR1A	HTR1D	ENSOCUP00000008436	ENSOCUP00000009551	G_PROTEIN_RECEP_F1_2 domain-containing protein.	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	0.549
HTR1A	HTR2A	ENSOCUP00000008436	ENSOCUP00000008591	G_PROTEIN_RECEP_F1_2 domain-containing protein.	5-hydroxytryptamine receptor 2A.	0.455
HTR1A	HTR2C	ENSOCUP00000008436	ENSOCUP00000013659	G_PROTEIN_RECEP_F1_2 domain-containing protein.	5-hydroxytryptamine receptor 2C.	0.432
HTR1A	SLC6A4	ENSOCUP00000008436	ENSOCUP00000003158	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.742
HTR1A	TPH2	ENSOCUP00000008436	ENSOCUP00000049818	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Tryptophan hydroxylase 2.	0.460
HTR1D	HTR1A	ENSOCUP00000009551	ENSOCUP00000008436	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.549
HTR1D	HTR2A	ENSOCUP00000009551	ENSOCUP00000008591	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	5-hydroxytryptamine receptor 2A.	0.477
HTR1D	HTR2B	ENSOCUP00000009551	ENSOCUP00000007414	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	5-hydroxytryptamine receptor 2B.	0.453
HTR1D	SLC6A4	ENSOCUP00000009551	ENSOCUP00000003158	5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...]	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.720