STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LCKTyrosine-protein kinase. (637 aa)    
Predicted Functional Partners:
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
   
 0.999
ZAP70
Tyrosine-protein kinase.
   
0.996
PTPRC
Protein tyrosine phosphatase receptor type C.
   
 0.987
FYN
Tyrosine-protein kinase.
  
0.984
CD8A
Ig-like domain-containing protein.
   
 0.974
CBLB
Cbl proto-oncogene B.
    
 0.952
TYROBP
TYRO protein tyrosine kinase binding protein.
   
 0.945
CD8B
Ig-like domain-containing protein.
   
 
 0.943
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.937
LAT
Linker for activation of T cells.
   
 0.894
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (32%) [HD]