MSMO1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

MSMO1

Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (292 aa)

Predicted Functional Partners:

NSDHL

0.986

CYP51A1

0.985

SQLE

0.985

SC5D

0.969

TM7SF2

0.959

HMGCS1

0.953

FDFT1

0.953

DHCR24

0.951

CYP7A1

0.917

CYP7B1

0.917

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP51A1	CYP7B1	ENSOCUP00000003924	ENSOCUP00000032097	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.456
CYP51A1	DHCR24	ENSOCUP00000003924	ENSOCUP00000004499	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	24-dehydrocholesterol reductase.	0.985
CYP51A1	FDFT1	ENSOCUP00000003924	ENSOCUP00000027128	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Farnesyl-diphosphate farnesyltransferase 1.	0.977
CYP51A1	HMGCS1	ENSOCUP00000003924	ENSOCUP00000003090	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.977
CYP51A1	MSMO1	ENSOCUP00000003924	ENSOCUP00000003265	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.	0.985
CYP51A1	NSDHL	ENSOCUP00000003924	ENSOCUP00000039549	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.979
CYP51A1	SC5D	ENSOCUP00000003924	ENSOCUP00000009757	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.967
CYP51A1	SQLE	ENSOCUP00000003924	ENSOCUP00000049920	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Squalene epoxidase.	0.993
CYP51A1	TM7SF2	ENSOCUP00000003924	ENSOCUP00000036677	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.988
CYP7A1	DHCR24	ENSOCUP00000010572	ENSOCUP00000004499	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	24-dehydrocholesterol reductase.	0.930
CYP7A1	FDFT1	ENSOCUP00000010572	ENSOCUP00000027128	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Farnesyl-diphosphate farnesyltransferase 1.	0.715
CYP7A1	HMGCS1	ENSOCUP00000010572	ENSOCUP00000003090	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.746
CYP7A1	MSMO1	ENSOCUP00000010572	ENSOCUP00000003265	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.	0.917
CYP7A1	NSDHL	ENSOCUP00000010572	ENSOCUP00000039549	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.672
CYP7A1	SC5D	ENSOCUP00000010572	ENSOCUP00000009757	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.709
CYP7A1	SQLE	ENSOCUP00000010572	ENSOCUP00000049920	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Squalene epoxidase.	0.886
CYP7A1	TM7SF2	ENSOCUP00000010572	ENSOCUP00000036677	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Uncharacterized protein.	0.732
CYP7B1	CYP51A1	ENSOCUP00000032097	ENSOCUP00000003924	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	0.456
CYP7B1	DHCR24	ENSOCUP00000032097	ENSOCUP00000004499	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	24-dehydrocholesterol reductase.	0.646
CYP7B1	FDFT1	ENSOCUP00000032097	ENSOCUP00000027128	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Farnesyl-diphosphate farnesyltransferase 1.	0.656