node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT | DMGDH | ENSOCUP00000022506 | ENSOCUP00000030807 | Serine--pyruvate aminotransferase. | Dimethylglycine dehydrogenase. | 0.539 |
AGXT | ENSOCUP00000044443 | ENSOCUP00000022506 | ENSOCUP00000044443 | Serine--pyruvate aminotransferase. | DAO domain-containing protein. | 0.951 |
AGXT | GATM | ENSOCUP00000022506 | ENSOCUP00000029330 | Serine--pyruvate aminotransferase. | Glycine amidinotransferase. | 0.915 |
AGXT | GCAT | ENSOCUP00000022506 | ENSOCUP00000033229 | Serine--pyruvate aminotransferase. | Aminotran_1_2 domain-containing protein. | 0.938 |
AGXT | GLDC | ENSOCUP00000022506 | ENSOCUP00000003560 | Serine--pyruvate aminotransferase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.967 |
AGXT | GNMT | ENSOCUP00000022506 | ENSOCUP00000003341 | Serine--pyruvate aminotransferase. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. | 0.948 |
AGXT | PIPOX | ENSOCUP00000022506 | ENSOCUP00000013124 | Serine--pyruvate aminotransferase. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.962 |
AGXT | SARDH | ENSOCUP00000022506 | ENSOCUP00000018289 | Serine--pyruvate aminotransferase. | Uncharacterized protein. | 0.951 |
AGXT | SHMT1 | ENSOCUP00000022506 | ENSOCUP00000017814 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.991 |
AGXT | SHMT2 | ENSOCUP00000022506 | ENSOCUP00000019769 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.990 |
DMGDH | AGXT | ENSOCUP00000030807 | ENSOCUP00000022506 | Dimethylglycine dehydrogenase. | Serine--pyruvate aminotransferase. | 0.539 |
DMGDH | ENSOCUP00000044443 | ENSOCUP00000030807 | ENSOCUP00000044443 | Dimethylglycine dehydrogenase. | DAO domain-containing protein. | 0.952 |
DMGDH | GLDC | ENSOCUP00000030807 | ENSOCUP00000003560 | Dimethylglycine dehydrogenase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.913 |
DMGDH | GNMT | ENSOCUP00000030807 | ENSOCUP00000003341 | Dimethylglycine dehydrogenase. | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. | 0.977 |
DMGDH | PIPOX | ENSOCUP00000030807 | ENSOCUP00000013124 | Dimethylglycine dehydrogenase. | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline. | 0.964 |
DMGDH | SARDH | ENSOCUP00000030807 | ENSOCUP00000018289 | Dimethylglycine dehydrogenase. | Uncharacterized protein. | 0.935 |
DMGDH | SHMT1 | ENSOCUP00000030807 | ENSOCUP00000017814 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.798 |
DMGDH | SHMT2 | ENSOCUP00000030807 | ENSOCUP00000019769 | Dimethylglycine dehydrogenase. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.775 |
ENSOCUP00000044443 | AGXT | ENSOCUP00000044443 | ENSOCUP00000022506 | DAO domain-containing protein. | Serine--pyruvate aminotransferase. | 0.951 |
ENSOCUP00000044443 | DMGDH | ENSOCUP00000044443 | ENSOCUP00000030807 | DAO domain-containing protein. | Dimethylglycine dehydrogenase. | 0.952 |