PRIMPOL protein (Oryctolagus cuniculus) - STRING interaction network

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Predicted Interactions

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Score

PRIMPOL

Uncharacterized protein. (552 aa)

Predicted Functional Partners:

RPA1

0.989

SMARCAL1

0.988

CLSPN

0.964

RPA3

0.959

TIPIN

0.956

TIMELESS

0.955

RFWD3

0.952

ZRANB3

0.864

RPA2

0.829

HLTF

0.731

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSPN	PRIMPOL	ENSOCUP00000014949	ENSOCUP00000003383	Claspin.	Uncharacterized protein.	0.964
CLSPN	RPA1	ENSOCUP00000014949	ENSOCUP00000042935	Claspin.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.980
CLSPN	RPA2	ENSOCUP00000014949	ENSOCUP00000013917	Claspin.	Replication protein A2.	0.903
CLSPN	RPA3	ENSOCUP00000014949	ENSOCUP00000000408	Claspin.	Replication protein A3.	0.984
CLSPN	SMARCAL1	ENSOCUP00000014949	ENSOCUP00000008523	Claspin.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.554
CLSPN	TIMELESS	ENSOCUP00000014949	ENSOCUP00000010377	Claspin.	Timeless circadian regulator.	0.990
CLSPN	TIPIN	ENSOCUP00000014949	ENSOCUP00000001908	Claspin.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.995
CLSPN	ZRANB3	ENSOCUP00000014949	ENSOCUP00000038477	Claspin.	Zinc finger RANBP2-type containing 3.	0.457
HLTF	PRIMPOL	ENSOCUP00000047915	ENSOCUP00000003383	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	Uncharacterized protein.	0.731
HLTF	RFWD3	ENSOCUP00000047915	ENSOCUP00000007899	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	Ring finger and WD repeat domain 3.	0.554
HLTF	RPA1	ENSOCUP00000047915	ENSOCUP00000042935	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.654
HLTF	RPA3	ENSOCUP00000047915	ENSOCUP00000000408	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	Replication protein A3.	0.501
HLTF	SMARCAL1	ENSOCUP00000047915	ENSOCUP00000008523	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.603
HLTF	TIMELESS	ENSOCUP00000047915	ENSOCUP00000010377	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	Timeless circadian regulator.	0.418
HLTF	TIPIN	ENSOCUP00000047915	ENSOCUP00000001908	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.468
HLTF	ZRANB3	ENSOCUP00000047915	ENSOCUP00000038477	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	Zinc finger RANBP2-type containing 3.	0.593
PRIMPOL	CLSPN	ENSOCUP00000003383	ENSOCUP00000014949	Uncharacterized protein.	Claspin.	0.964
PRIMPOL	HLTF	ENSOCUP00000003383	ENSOCUP00000047915	Uncharacterized protein.	Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Mediates repression by c-Rel through a DNA-looping mechanism. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination o [...]	0.731
PRIMPOL	RFWD3	ENSOCUP00000003383	ENSOCUP00000007899	Uncharacterized protein.	Ring finger and WD repeat domain 3.	0.952
PRIMPOL	RPA1	ENSOCUP00000003383	ENSOCUP00000042935	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.989