Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TMEM86ATransmembrane protein 86A. (391 aa)    
Predicted Functional Partners:
TMEM86B
Transmembrane protein 86B.
  
  
0.883
GDPD1
Glycerophosphodiester phosphodiesterase domain containing 1.
     
 0.865
GDPD3
Glycerophosphodiester phosphodiesterase domain containing 3.
     
 0.865
PLAAT2
Phospholipase A and acyltransferase 2.
   
 
  0.853
PLAAT3
Phospholipase A and acyltransferase 3.
   
 
  0.853
PLA2G1B
Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family.
   
 
  0.852
PLA2G2F
Phospholipase A(2).
   
 
  0.852
PLA2G2E
Phospholipase A(2).
   
 
  0.852
PLA2G2A
Phospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferat [...]
   
 
  0.852
PLA2G2D
Phospholipase A(2).
   
 
  0.852
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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