Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
DENND3WD_REPEATS_REGION domain-containing protein. (248 aa)    
Predicted Functional Partners:
RAB12
RAB12, member RAS oncogene family.
    
 0.905
DENND5B
DENN domain containing 5B.
    
 
 0.833
ULK1
Unc-51 like autophagy activating kinase 1.
    
 0.832
DENND5A
DENN domain containing 5A.
    
 
 0.775
RAB28
RAB28, member RAS oncogene family.
    
 0.674
ULK2
Unc-51 like autophagy activating kinase 2.
    
 0.667
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
  
 0.658
TBATA
Thymus, brain and testes associated.
      
 0.649
DENND2B
Suppression of tumorigenicity 5.
    
   0.634
CHM
Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
     
 0.629
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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