SOCS4 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

SOCS4

Suppressor of cytokine signaling 4. (441 aa)

Predicted Functional Partners:

JAK2

0.968

JAK1

0.966

ELOB

0.963

STAT3

0.962

STAT1

0.959

ELOC

0.958

STAT5A

0.957

SOCS2

0.954

STAT5B

0.952

CUL5

0.943

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL5	ELOB	ENSOCUP00000009389	ENSOCUP00000008716	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Elongin B.	0.999
CUL5	ELOC	ENSOCUP00000009389	ENSOCUP00000033796	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Elongin C; Belongs to the SKP1 family.	0.999
CUL5	JAK1	ENSOCUP00000009389	ENSOCUP00000005398	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase.	0.497
CUL5	JAK2	ENSOCUP00000009389	ENSOCUP00000014491	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Tyrosine-protein kinase.	0.585
CUL5	SOCS2	ENSOCUP00000009389	ENSOCUP00000001084	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 2.	0.983
CUL5	SOCS4	ENSOCUP00000009389	ENSOCUP00000003465	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Suppressor of cytokine signaling 4.	0.943
ELOB	CUL5	ENSOCUP00000008716	ENSOCUP00000009389	Elongin B.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.999
ELOB	ELOC	ENSOCUP00000008716	ENSOCUP00000033796	Elongin B.	Elongin C; Belongs to the SKP1 family.	0.999
ELOB	JAK1	ENSOCUP00000008716	ENSOCUP00000005398	Elongin B.	Tyrosine-protein kinase.	0.520
ELOB	JAK2	ENSOCUP00000008716	ENSOCUP00000014491	Elongin B.	Tyrosine-protein kinase.	0.562
ELOB	SOCS2	ENSOCUP00000008716	ENSOCUP00000001084	Elongin B.	Suppressor of cytokine signaling 2.	0.929
ELOB	SOCS4	ENSOCUP00000008716	ENSOCUP00000003465	Elongin B.	Suppressor of cytokine signaling 4.	0.963
ELOC	CUL5	ENSOCUP00000033796	ENSOCUP00000009389	Elongin C; Belongs to the SKP1 family.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.999
ELOC	ELOB	ENSOCUP00000033796	ENSOCUP00000008716	Elongin C; Belongs to the SKP1 family.	Elongin B.	0.999
ELOC	JAK1	ENSOCUP00000033796	ENSOCUP00000005398	Elongin C; Belongs to the SKP1 family.	Tyrosine-protein kinase.	0.405
ELOC	JAK2	ENSOCUP00000033796	ENSOCUP00000014491	Elongin C; Belongs to the SKP1 family.	Tyrosine-protein kinase.	0.495
ELOC	SOCS2	ENSOCUP00000033796	ENSOCUP00000001084	Elongin C; Belongs to the SKP1 family.	Suppressor of cytokine signaling 2.	0.916
ELOC	SOCS4	ENSOCUP00000033796	ENSOCUP00000003465	Elongin C; Belongs to the SKP1 family.	Suppressor of cytokine signaling 4.	0.958
JAK1	CUL5	ENSOCUP00000005398	ENSOCUP00000009389	Tyrosine-protein kinase.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.497
JAK1	ELOB	ENSOCUP00000005398	ENSOCUP00000008716	Tyrosine-protein kinase.	Elongin B.	0.520