node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP17A1 | FDX1 | ENSOCUP00000015281 | ENSOCUP00000046511 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | 2Fe-2S ferredoxin-type domain-containing protein. | 0.677 |
CYP17A1 | HSD11B1 | ENSOCUP00000015281 | ENSOCUP00000003489 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | 0.751 |
CYP17A1 | HSD11B2 | ENSOCUP00000015281 | ENSOCUP00000037332 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.598 |
CYP17A1 | HSD17B3 | ENSOCUP00000015281 | ENSOCUP00000007373 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.988 |
CYP17A1 | LHCGR | ENSOCUP00000015281 | ENSOCUP00000027034 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.902 |
CYP17A1 | SCARB1 | ENSOCUP00000015281 | ENSOCUP00000037035 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | Scavenger receptor class B member 1; Belongs to the CD36 family. | 0.747 |
CYP17A1 | SRD5A1 | ENSOCUP00000015281 | ENSOCUP00000014623 | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.984 |
FDX1 | CYP17A1 | ENSOCUP00000046511 | ENSOCUP00000015281 | 2Fe-2S ferredoxin-type domain-containing protein. | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.677 |
FDX1 | H6PD | ENSOCUP00000046511 | ENSOCUP00000000694 | 2Fe-2S ferredoxin-type domain-containing protein. | GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6- phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6- phosphogluconolactonase and ca [...] | 0.449 |
FDX1 | HSD11B1 | ENSOCUP00000046511 | ENSOCUP00000003489 | 2Fe-2S ferredoxin-type domain-containing protein. | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | 0.670 |
H6PD | FDX1 | ENSOCUP00000000694 | ENSOCUP00000046511 | GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6- phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6- phosphogluconolactonase and ca [...] | 2Fe-2S ferredoxin-type domain-containing protein. | 0.449 |
H6PD | HSD11B1 | ENSOCUP00000000694 | ENSOCUP00000003489 | GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6- phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6- phosphogluconolactonase and ca [...] | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | 0.706 |
H6PD | HSD11B2 | ENSOCUP00000000694 | ENSOCUP00000037332 | GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6- phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6- phosphogluconolactonase and ca [...] | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.585 |
HSD11B1 | CYP17A1 | ENSOCUP00000003489 | ENSOCUP00000015281 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.751 |
HSD11B1 | FDX1 | ENSOCUP00000003489 | ENSOCUP00000046511 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | 2Fe-2S ferredoxin-type domain-containing protein. | 0.670 |
HSD11B1 | H6PD | ENSOCUP00000003489 | ENSOCUP00000000694 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6- phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6- phosphogluconolactonase and ca [...] | 0.706 |
HSD11B1 | HSD11B2 | ENSOCUP00000003489 | ENSOCUP00000037332 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. | 0.953 |
HSD11B1 | HSD17B3 | ENSOCUP00000003489 | ENSOCUP00000007373 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.772 |
HSD11B1 | LHCGR | ENSOCUP00000003489 | ENSOCUP00000027034 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.687 |
HSD11B1 | NR3C1 | ENSOCUP00000003489 | ENSOCUP00000046838 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] | 0.751 |