Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PLA2G3Phospholipase A2 group III. (636 aa)    
Predicted Functional Partners:
PLA2G2D
Phospholipase A(2).
     
 0.967
PLA2G15
Phospholipase A2 group XV.
     
 0.955
PLA2G10
Phospholipase A(2).
     
 0.948
PLA2G10-2
Phospholipase A(2).
     
 0.948
PLA2G2F
Phospholipase A(2).
   
 
 0.939
PLA2G2E
Phospholipase A(2).
     
 0.930
PLA2G2A
Phospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferat [...]
     
 0.924
PLA2G7
Platelet-activating factor acetylhydrolase.
   
 
 0.916
PLA2G2C
Phospholipase A(2).
     
 0.915
PLAAT3
Phospholipase A and acyltransferase 3.
     
 0.908
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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