Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRRT3Proline rich transmembrane protein 3. (1025 aa)    
Predicted Functional Partners:
FAM229B
Family with sequence similarity 229 member B.
   
  
 0.709
GASK1A
Golgi associated kinase 1A.
      
 0.702
NEDD8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).
   
 0.692
ZZEF1
Zinc finger ZZ-type and EF-hand domain containing 1.
   
  
 0.666
C1QTNF2
C1q and TNF related 2.
    
 
 0.593
TMCC2
Transmembrane and coiled-coil domain family 2.
      
 0.590
NFU1
NFU1 iron-sulfur cluster scaffold.
   
  
 0.579
ZC3H8
Zinc finger CCCH-type containing 8.
      
 0.573
TTC25
Tetratricopeptide repeat domain 25.
    
 
 0.567
TBC1D10C
TBC1 domain family member 10C.
   
  
 0.566
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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