TIGIT protein (Oryctolagus cuniculus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

TIGIT

T cell immunoreceptor with Ig and ITIM domains. (245 aa)

Predicted Functional Partners:

PVR

0.999

NECTIN2

0.995

NECTIN3

0.989

LGALS9

0.904

CD226

0.889

LAG3

0.884

CTLA4

0.876

CD80

0.851

CD96

0.815

HAVCR2

0.812

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD226	CD80	ENSOCUP00000010525	ENSOCUP00000008197	CD226 molecule.	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	0.459
CD226	CD96	ENSOCUP00000010525	ENSOCUP00000026545	CD226 molecule.	CD96 molecule.	0.448
CD226	CTLA4	ENSOCUP00000010525	ENSOCUP00000017677	CD226 molecule.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.612
CD226	NECTIN2	ENSOCUP00000010525	ENSOCUP00000015317	CD226 molecule.	Nectin cell adhesion molecule 2.	0.953
CD226	PVR	ENSOCUP00000010525	ENSOCUP00000017165	CD226 molecule.	Uncharacterized protein.	0.999
CD226	TIGIT	ENSOCUP00000010525	ENSOCUP00000003654	CD226 molecule.	T cell immunoreceptor with Ig and ITIM domains.	0.889
CD80	CD226	ENSOCUP00000008197	ENSOCUP00000010525	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	CD226 molecule.	0.459
CD80	CTLA4	ENSOCUP00000008197	ENSOCUP00000017677	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.999
CD80	HAVCR2	ENSOCUP00000008197	ENSOCUP00000036967	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	Uncharacterized protein.	0.514
CD80	LAG3	ENSOCUP00000008197	ENSOCUP00000009632	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	Lymphocyte activating 3.	0.685
CD80	LGALS9	ENSOCUP00000008197	ENSOCUP00000037330	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	Galectin.	0.563
CD80	TIGIT	ENSOCUP00000008197	ENSOCUP00000003654	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	T cell immunoreceptor with Ig and ITIM domains.	0.851
CD96	CD226	ENSOCUP00000026545	ENSOCUP00000010525	CD96 molecule.	CD226 molecule.	0.448
CD96	CTLA4	ENSOCUP00000026545	ENSOCUP00000017677	CD96 molecule.	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	0.466
CD96	NECTIN2	ENSOCUP00000026545	ENSOCUP00000015317	CD96 molecule.	Nectin cell adhesion molecule 2.	0.796
CD96	PVR	ENSOCUP00000026545	ENSOCUP00000017165	CD96 molecule.	Uncharacterized protein.	0.976
CD96	TIGIT	ENSOCUP00000026545	ENSOCUP00000003654	CD96 molecule.	T cell immunoreceptor with Ig and ITIM domains.	0.815
CTLA4	CD226	ENSOCUP00000017677	ENSOCUP00000010525	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	CD226 molecule.	0.612
CTLA4	CD80	ENSOCUP00000017677	ENSOCUP00000008197	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.	0.999
CTLA4	CD96	ENSOCUP00000017677	ENSOCUP00000026545	Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.	CD96 molecule.	0.466